Mouse BTEB3, a new member of the basic transcription element binding protein (BTEB) family, activates expression from GC-rich minimal promoter regions

被引：35

作者：

Martin, KM ^{[1
]}

Cooper, WN ^{[1
]}

Metcalfe, JC ^{[1
]}

Kemp, PR ^{[1
]}

机构：

[1] Univ Cambridge, Dept Biochem, Sect Cardiovasc Biol, Cambridge CB2 1QW, England

来源：

BIOCHEMICAL JOURNAL | 2000年 / 345卷

关键词：

basal transcription element; GC box; SM22 alpha promoter; SV40; promoter; transcription factor;

D O I：

10.1042/0264-6021:3450529

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Members of the three-zinc-finger family of transcription factors play an important role in determining basal transcription. We have cloned mouse BTEB3 (mBTEB3), a new member of the basic transcription element binding protein (BTEB) family, which is expressed in a wide variety of tissues. mBTEB3 activates transcription of the simian virus 40 early promoter (4-fold) and of the tissue-specific SM22 alpha promoter (100-fold), suggesting that, like BTEB1 and Spl, mBTEB3 is a basal transcription factor.

引用

页码：529 / 533

页数：5

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