HIV-1 assembly at the plasma membrane: Gag trafficking and localization

被引:71
作者
Ono, Akira [1 ]
机构
[1] Univ Michigan, Sch Med, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA
关键词
endosomal trafficking; Gag; late endosome/multivesicular body; membrane microdomain; membrane raft; phosphatidylinositol-(4,5)-bisphosphate; plasma membrane; tetraspanin; virological synapse; virus assembly; HUMAN-IMMUNODEFICIENCY-VIRUS; VIRION-ASSOCIATED CHOLESTEROL; TETRASPANIN-ENRICHED MICRODOMAINS; VIROLOGICAL SYNAPSE FORMATION; MONOCYTE-DERIVED MACROPHAGES; RETROVIRUS RNA TRAFFICKING; MURINE LEUKEMIA-VIRUS; B METHYL-ESTER; LIPID RAFTS; TYPE-1; GAG;
D O I
10.2217/FVL.09.4
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Virus particle formation of HIV-1 is a multistep process driven by a viral structural protein, Gag. This process takes place at the plasma membrane in most cell types. However, the pathway that directs Gag to the plasma membrane has recently come under intense scrutiny owing to its importance in the production of progeny virions, as well as virus transmission at cell-cell contacts, This article highlights recent advances in our current understanding of mechanisms that traffic and localize Gag to the plasma membrane. In addition, findings on Gag association with specific plasma membrane domains are discussed in light of potential roles in cell-cell transmission.
引用
收藏
页码:241 / 257
页数:17
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