Advances in CAR T cell immunotherapy for paediatric brain tumours

被引：5

作者：

Rao, Padmashree ^{[1
]}

Furst, Liam ^{[2
,3
]}

Meyran, Deborah ^{[4
,5
,6
,7
]}

Mayoh, Chelsea ^{[1
,8
]}

Neeson, Paul J. ^{[4
,5
]}

Terry, Rachael ^{[1
,8
]}

Khuong-Quang, Dong-Anh ^{[1
,3
,7
]}

Mantamadiotis, Theo ^{[2
,9
]}

Ekert, Paul G. ^{[1
,3
,4
,5
,8
,10
]}

机构：

[1] Childrens Canc Inst, Translat Tumour Biol, Randwick, NSW, Australia

[2] Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic, Australia

[3] Royal Childrens Hosp, Murdoch Childrens Res Inst, Melbourne, Vic, Australia

[4] Peter MacCallum Canc Ctr, Canc Immunol Program, Melbourne, Vic, Australia

[5] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia

[6] Univ Paris, Inst Rech St Louis, Inserm, Human Immunol Pathophysiol Immunotherapy HIPI Unit, Paris, France

[7] Royal Childrens Hosp, Childrens Canc Ctr, Parkville, Vic, Australia

[8] Univ New South Wales, Sch Women & Childrens Hlth, Randwick, NSW, Australia

[9] Univ Melbourne, Royal Melbourne Hosp RMH, Dept Surg, Parkville, Vic, Australia

[10] Univ Melbourne, Dept Paediat, Parkville, Vic, Australia

来源：

FRONTIERS IN ONCOLOGY | 2022年 / 12卷

基金：

英国医学研究理事会;

关键词：

CAR T cell; immunotherapy; paediatric brain tumour; tumour microenvironment; blood brain barrier; CYTOKINE RELEASE SYNDROME; CANCER; GLIOBLASTOMA; REGRESSION; LANDSCAPE; SURVIVAL; MUTATION; ANTIBODY; THERAPY; SYSTEM;

D O I：

10.3389/fonc.2022.873722

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Brain tumours are the most common solid tumour in children and the leading cause of cancer related death in children. Current treatments include surgery, chemotherapy and radiotherapy. The need for aggressive treatment means many survivors are left with permanent severe disability, physical, intellectual and social. Recent progress in immunotherapy, including genetically engineered T cells with chimeric antigen receptors (CARs) for treating cancer, may provide new avenues to improved outcomes for patients with paediatric brain cancer. In this review we discuss advances in CAR T cell immunotherapy, the major CAR T cell targets that are in clinical and pre-clinical development with a focus on paediatric brain tumours, the paediatric brain tumour microenvironment and strategies used to improve CAR T cell therapy for paediatric tumours.

引用

页数：11

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