Advances in CAR T cell immunotherapy for paediatric brain tumours

被引：5

作者：

Rao, Padmashree ^{[1
]}

Furst, Liam ^{[2
,3
]}

Meyran, Deborah ^{[4
,5
,6
,7
]}

Mayoh, Chelsea ^{[1
,8
]}

Neeson, Paul J. ^{[4
,5
]}

Terry, Rachael ^{[1
,8
]}

Khuong-Quang, Dong-Anh ^{[1
,3
,7
]}

Mantamadiotis, Theo ^{[2
,9
]}

Ekert, Paul G. ^{[1
,3
,4
,5
,8
,10
]}

机构：

[1] Childrens Canc Inst, Translat Tumour Biol, Randwick, NSW, Australia

[2] Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic, Australia

[3] Royal Childrens Hosp, Murdoch Childrens Res Inst, Melbourne, Vic, Australia

[4] Peter MacCallum Canc Ctr, Canc Immunol Program, Melbourne, Vic, Australia

[5] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia

[6] Univ Paris, Inst Rech St Louis, Inserm, Human Immunol Pathophysiol Immunotherapy HIPI Unit, Paris, France

[7] Royal Childrens Hosp, Childrens Canc Ctr, Parkville, Vic, Australia

[8] Univ New South Wales, Sch Women & Childrens Hlth, Randwick, NSW, Australia

[9] Univ Melbourne, Royal Melbourne Hosp RMH, Dept Surg, Parkville, Vic, Australia

[10] Univ Melbourne, Dept Paediat, Parkville, Vic, Australia

来源：

FRONTIERS IN ONCOLOGY | 2022年 / 12卷

基金：

英国医学研究理事会;

关键词：

CAR T cell; immunotherapy; paediatric brain tumour; tumour microenvironment; blood brain barrier; CYTOKINE RELEASE SYNDROME; CANCER; GLIOBLASTOMA; REGRESSION; LANDSCAPE; SURVIVAL; MUTATION; ANTIBODY; THERAPY; SYSTEM;

D O I：

10.3389/fonc.2022.873722

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Brain tumours are the most common solid tumour in children and the leading cause of cancer related death in children. Current treatments include surgery, chemotherapy and radiotherapy. The need for aggressive treatment means many survivors are left with permanent severe disability, physical, intellectual and social. Recent progress in immunotherapy, including genetically engineered T cells with chimeric antigen receptors (CARs) for treating cancer, may provide new avenues to improved outcomes for patients with paediatric brain cancer. In this review we discuss advances in CAR T cell immunotherapy, the major CAR T cell targets that are in clinical and pre-clinical development with a focus on paediatric brain tumours, the paediatric brain tumour microenvironment and strategies used to improve CAR T cell therapy for paediatric tumours.

引用

页数：11

共 86 条

[1] A Phase I Trial of Regional Mesothelin-Targeted CAR T-cell Therapy in Patients with Malignant Pleural Disease, in Combination with the Anti-PD-1 Agent Pembrolizumab
Adusumilli, Prasad S.
Zauderer, Marjorie G.
Riviere, Isabelle
Solomon, Stephen B.
Rusch, Valerie W.
O'Cearbhaill, Roisin E.
Zhu, Amy
Cheema, Waseem
Chintala, Navin K.
Halton, Elizabeth
Pineda, John
Perez-Johnston, Rocio
Tan, Kay See
Daly, Bobby
Araujo Filho, Jose A.
Ngai, Daniel
McGee, Erin
Vincent, Alain
Diamonte, Claudia
Sauter, Jennifer L.
Modi, Shanu
Sikder, Devanjan
Senechal, Brigitte
Wang, Xiuyan
Travis, William D.
Gonen, Mithat
Rudin, Charles M.
Brentjens, Renier J.
Jones, David R.
Sadelain, Michel
[J]. CANCER DISCOVERY, 2021, 11 (11) : 2748 - 2763
[2] Ahmed N., 2015, J Immuno Cancer, V3, pO11, DOI [DOI 10.1186/2051-1426-3-S2-O11, 10.1186/2051-1426-3-S2-O11]
[3] CAR T cells for brain tumors: Lessons learned and road ahead
Akhavan, David
Alizadeh, Darya
Wang, Dongrui
Weist, Michael R.
Shepphird, Jennifer K.
Brown, Christine E.
[J]. IMMUNOLOGICAL REVIEWS, 2019, 290 (01) : 60 - 84
[4] Adult Glioblastoma
Alexander, Brian M.
Cloughesy, Timothy F.
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (21) : 2402 - +
[5] The blood-brain barrier and blood-tumour barrier in brain tumours and metastases
Arvanitis, Costas D.
Ferraro, Gino B.
Jain, Rakesh K.
[J]. NATURE REVIEWS CANCER, 2020, 20 (01) : 26 - 41
[6] Childhood Atypical Teratoid Rhabdoid Tumor of the Central Nervous System A Meta-Analysis of Observational Studies
Athale, Uma H.
Duckworth, JoAnn
Odame, Isaac
Barr, Ronald
[J]. JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2009, 31 (09) : 651 - 663
[7] BARKER CF, 1977, ADV IMMUNOL, V25, P1
[8] Interleukin 6 Is Not Made By Chimeric Antigen Receptor T Cells and Does Not Impact Their Function
Barrett, David M.
Singh, Nathan
Hofmann, Ted J.
Gershenson, Zachary
Grupp, Stephan A.
[J]. BLOOD, 2016, 128 (22)
[9] EGFRvIII Deletion Mutations in Pediatric High-Grade Glioma and Response to Targeted Therapy in Pediatric Glioma Cell Lines
Bax, Dorine A.
Gaspar, Nathalie
Little, Suzanne E.
Marshall, Lynley
Perryman, Lara
Regairaz, Marie
Viana-Pereira, Marta
Vuononvirta, Raisa
Sharp, Swee Y.
Reis-Filho, Jorge S.
Stavale, Joao N.
Al-Sarraj, Safa
Reis, Rui M.
Vassal, Gilles
Pearson, Andrew D. J.
Hargrave, Darren
Ellison, David W.
Workman, Paul
Jones, Chris
[J]. CLINICAL CANCER RESEARCH, 2009, 15 (18) : 5753 - 5761
[10] The cumulative burden of surviving childhood cancer: an initial report from the St Jude Lifetime Cohort Study (SJLIFE)
Bhakta, Nickhill
Liu, Qi
Ness, Kirsten K.
Baassiri, Malek
Eissa, Hesham
Yeo, Frederick
Chemaitilly, Wassim
Ehrhardt, Matthew J.
Bass, Johnnie
Bishop, Michael W.
Shelton, Kyla
Lu, Lu
Huang, Sujuan
Li, Zhenghong
Caron, Eric
Lanctot, Jennifer
Howell, Carrie
Folse, Timothy
Joshi, Vijaya
Green, Daniel M.
Mulrooney, Daniel A.
Armstrong, Gregory T.
Krull, Kevin R.
Brinkman, Tara M.
Khan, Raja B.
Srivastava, Deo K.
Hudson, Melissa M.
Yasui, Yutaka
Robison, Leslie L.
[J]. LANCET, 2017, 390 (10112) : 2569 - 2582

← 1 2 3 4 5 6 7 8 9 →