Pulmonary Mycobacterium abscessus complex in children with cystic fibrosis: A practical management guideline

被引：14

作者：

Andrew, Eden C. ^{[1
]}

Connell, Tom ^{[1
,3
,4
]}

Robinson, Phil ^{[2
,3
,5
]}

Curtis, Nigel ^{[1
,3
,4
]}

Massie, John ^{[2
,3
,5
]}

Robertson, Colin ^{[2
,3
,5
]}

Harrison, Joanne ^{[2
,3
,5
]}

Shanthikumar, Shivanthan ^{[2
,3
,5
]}

Bryant, Penelope A. ^{[1
,3
,4
]}

Starr, Mike ^{[1
,3
]}

Steer, Andrew ^{[1
,3
,6
]}

Ranganathan, Sarath ^{[2
,3
,5
]}

Gwee, Amanda ^{[1
,3
,4
]}

机构：

[1] Univ Melbourne, Royal Childrens Hosp Melbourne, Dept Gen Med, Infect Dis Unit, Melbourne, Vic, Australia

[2] Univ Melbourne, Royal Childrens Hosp Melbourne, Dept Resp & Sleep Med, Melbourne, Vic, Australia

[3] Univ Melbourne, Dept Pediat, Melbourne, Vic, Australia

[4] Murdoch Childrens Res Inst, Clin Infect Dis Grp, Melbourne, Vic, Australia

[5] Murdoch Childrens Res Inst, Resp Dis, Melbourne, Vic, Australia

[6] Murdoch Childrens Res Inst, Grp A Streptococcal, Res Grp, Melbourne, Vic, Australia

来源：

JOURNAL OF PAEDIATRICS AND CHILD HEALTH | 2019年 / 55卷 / 05期

关键词：

cystic fibrosis; Mycobacterium abscessus; non-tuberculous mycobacteria; paediatric; NONTUBERCULOUS MYCOBACTERIA; CLINICAL-SIGNIFICANCE; INFECTIONS; AMIKACIN; PHARMACOKINETICS; SUSCEPTIBILITY; AZITHROMYCIN; TIGECYCLINE; EXPERIENCE; RESISTANCE;

D O I：

10.1111/jpc.14427

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The treatment of Mycobacterium abscessus complex (MABSC) pulmonary infections is an emerging challenge in patients with cystic fibrosis (CF). Multidrug therapy for prolonged durations is required and carries the significant burden of drug-related toxicity, cost and selective pressure for multiresistant bacteria. International guidelines acknowledge that clinical and in vitro data to support treatment regimens are limited, particularly in children. As part of a collaboration between the infectious diseases and respiratory units at our institution, we have developed a modified treatment guideline that aims to balance the aims of MABSC eradication and slowing disease progression with minimising drug toxicity and resistance. The outcomes of this treatment approach will be monitored and reported. In this manuscript, we discuss the available evidence for treatment choices and present our treatment guideline for paediatric patients with CF and MABSC infection.

引用

页码：502 / 511

页数：10

共 48 条

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