Pulmonary Mycobacterium abscessus complex in children with cystic fibrosis: A practical management guideline

被引:14
作者
Andrew, Eden C. [1 ]
Connell, Tom [1 ,3 ,4 ]
Robinson, Phil [2 ,3 ,5 ]
Curtis, Nigel [1 ,3 ,4 ]
Massie, John [2 ,3 ,5 ]
Robertson, Colin [2 ,3 ,5 ]
Harrison, Joanne [2 ,3 ,5 ]
Shanthikumar, Shivanthan [2 ,3 ,5 ]
Bryant, Penelope A. [1 ,3 ,4 ]
Starr, Mike [1 ,3 ]
Steer, Andrew [1 ,3 ,6 ]
Ranganathan, Sarath [2 ,3 ,5 ]
Gwee, Amanda [1 ,3 ,4 ]
机构
[1] Univ Melbourne, Royal Childrens Hosp Melbourne, Dept Gen Med, Infect Dis Unit, Melbourne, Vic, Australia
[2] Univ Melbourne, Royal Childrens Hosp Melbourne, Dept Resp & Sleep Med, Melbourne, Vic, Australia
[3] Univ Melbourne, Dept Pediat, Melbourne, Vic, Australia
[4] Murdoch Childrens Res Inst, Clin Infect Dis Grp, Melbourne, Vic, Australia
[5] Murdoch Childrens Res Inst, Resp Dis, Melbourne, Vic, Australia
[6] Murdoch Childrens Res Inst, Grp A Streptococcal, Res Grp, Melbourne, Vic, Australia
关键词
cystic fibrosis; Mycobacterium abscessus; non-tuberculous mycobacteria; paediatric; NONTUBERCULOUS MYCOBACTERIA; CLINICAL-SIGNIFICANCE; INFECTIONS; AMIKACIN; PHARMACOKINETICS; SUSCEPTIBILITY; AZITHROMYCIN; TIGECYCLINE; EXPERIENCE; RESISTANCE;
D O I
10.1111/jpc.14427
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
The treatment of Mycobacterium abscessus complex (MABSC) pulmonary infections is an emerging challenge in patients with cystic fibrosis (CF). Multidrug therapy for prolonged durations is required and carries the significant burden of drug-related toxicity, cost and selective pressure for multiresistant bacteria. International guidelines acknowledge that clinical and in vitro data to support treatment regimens are limited, particularly in children. As part of a collaboration between the infectious diseases and respiratory units at our institution, we have developed a modified treatment guideline that aims to balance the aims of MABSC eradication and slowing disease progression with minimising drug toxicity and resistance. The outcomes of this treatment approach will be monitored and reported. In this manuscript, we discuss the available evidence for treatment choices and present our treatment guideline for paediatric patients with CF and MABSC infection.
引用
收藏
页码:502 / 511
页数:10
相关论文
共 48 条
[1]   Epidemiology of Pulmonary Nontuberculous Mycobacterial Sputum Positivity in Patients with Cystic Fibrosis in the United States, 2010-2014 [J].
Adjemian, Jennifer ;
Olivier, Kenneth N. ;
Prevots, D. Rebecca .
ANNALS OF THE AMERICAN THORACIC SOCIETY, 2018, 15 (07) :817-826
[2]   Absolute bioavailability and intracellular pharmacokinetics of azithromycin in patients with cystic fibrosis [J].
Beringer, P ;
Huynh, KMT ;
Krengkauykiat, J ;
Bi, L ;
Hoem, N ;
Louie, S ;
Han, E ;
Nguyen, T ;
Hsu, D ;
Rao, PA ;
Shapiro, B ;
Gill, M .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (12) :5013-5017
[3]   Antimicrobial Susceptibility Testing, Drug Resistance Mechanisms, and Therapy of Infections with Nontuberculous Mycobacteria [J].
Brown-Elliott, Barbara A. ;
Nash, Kevin A. ;
Wallace, Richard J., Jr. .
CLINICAL MICROBIOLOGY REVIEWS, 2012, 25 (03) :545-+
[4]   Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium [J].
Bryant, Josephine M. ;
Grogono, Dorothy M. ;
Rodriguez-Rincon, Daniela ;
Everall, Isobel ;
Brown, Karen P. ;
Moreno, Pablo ;
Verma, Deepshikha ;
Hill, Emily ;
Drijkoningen, Judith ;
Gilligan, Peter ;
Esther, Charles R. ;
Noone, Peadar G. ;
Giddings, Olivia ;
Bell, Scott C. ;
Thomson, Rachel ;
Wainwright, Claire E. ;
Coulter, Chris ;
Pandey, Sushil ;
Wood, Michelle E. ;
Stockwell, Rebecca E. ;
Ramsay, Kay A. ;
Sherrard, Laura J. ;
Kidd, Timothy J. ;
Jabbour, Nassib ;
Johnson, Graham R. ;
Knibbs, Luke D. ;
Morawska, Lidia ;
Sly, Peter D. ;
Jones, Andrew ;
Bilton, Diana ;
Laurenson, Ian ;
Ruddy, Michael ;
Bourke, Stephen ;
Bowler, Ian C. J. W. ;
Chapman, Stephen J. ;
Clayton, Andrew ;
Cullen, Mairi ;
Dempsey, Owen ;
Denton, Miles ;
Desai, Maya ;
Drew, Richard J. ;
Edenborough, Frank ;
Evans, Jason ;
Folb, Jonathan ;
Daniels, Thomas ;
Humphrey, Helen ;
Isalska, Barbara ;
Jensen-Fangel, Soren ;
Jonsson, Bodil ;
Jones, Andrew M. .
SCIENCE, 2016, 354 (6313) :751-757
[5]   Whole-genome sequencing to identify transmission of Mycobacterium abscessus between patients with cystic fibrosis: a retrospective cohort study [J].
Bryant, Josephine M. ;
Grogono, Dorothy M. ;
Greaves, Daniel ;
Foweraker, Juliet ;
Roddick, Iain ;
Inns, Thomas ;
Reacher, Mark ;
Haworth, Charles S. ;
Curran, Martin D. ;
Harris, Simon R. ;
Peacock, Sharon J. ;
Parkhill, Julian ;
Floto, R. Andres .
LANCET, 2013, 381 (9877) :1551-1560
[6]   Mycobacterium avium and Mycobacterium abscessus complex target distinct cystic fibrosis patient subpopulations [J].
Catherinot, Emilie ;
Roux, Anne-Laure ;
Vibet, Marie-Anne ;
Bellis, Gil ;
Ravilly, Sophie ;
Lemonnier, Lydie ;
Le Roux, Evelyne ;
Bernede-Bauduin, Claire ;
Le Bourgeois, Muriel ;
Herrmann, Jean-Louis ;
Guillemot, Didier ;
Gaillard, Jean-Louis .
JOURNAL OF CYSTIC FIBROSIS, 2013, 12 (01) :74-80
[7]   Macrolide Treatment for Mycobacterium abscessus and Mycobacterium massillense Infection and Inducible Resistance [J].
Choi, Go-Eun ;
Shin, Sung Jae ;
Won, Choul-Jae ;
Min, Ki-Nam ;
Oh, Taegwon ;
Hahn, Mi-Young ;
Lee, Keehoon ;
Lee, Soo Hyun ;
Daley, Charles L. ;
Kim, Seonwoo ;
Jeong, Byeong-Ho ;
Jeon, Kyeongman ;
Koh, Won-Jung .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2012, 186 (09) :917-925
[8]   Activities of Moxifloxacin in Combination with Macrolides against Clinical Isolates of Mycobacterium abscessus and Mycobacterium massiliense [J].
Chol, Go-Eun ;
Min, Ki-Nam ;
Won, Choul-Jae ;
Jeon, Kyeongman ;
Shin, Sung Jae ;
Koh, Won-Jung .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2012, 56 (07) :3549-3555
[9]   A spatial epidemiological analysis of nontuberculous mycobacterial infections in Queensland, Australia [J].
Chou, Michael P. ;
Clements, Archie C. A. ;
Thomson, Rachel M. .
BMC INFECTIOUS DISEASES, 2014, 14
[10]  
Clinical and Laboratory Standards Institute, 2011, SUSCEPTIBILITY TESTI