Trifluoroethanol as a metal-free, homogeneous and recyclable medium for the efficient one-pot synthesis of α-amino nitriles and α-amino phosphonates

被引：69
作者：
Heydari, Akbar [1 ]
Khaksar, Samad [1 ]
Tajbakhsh, Mahmood [2 ]
机构：
[1] Tarbiat Modares Univ, Dept Chem, Tehran, Iran
[2] Mazandaran Univ, Dept Chem, Babol Sar 47415, Iran
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 01期
关键词：
Fluorous solvents; Trimethylsilyl cyanide; Trifluoroethanol; alpha-Amino phosphonates; alpha-Amino nitriles; Hydrogen bonding; ORGANIC PHOSPHORUS-COMPOUNDS; FACILE SYNTHESIS; ENANTIOSELECTIVE ADDITION; 3-COMPONENT CONDENSATION; LANTHANIDE TRIFLATE; SOLVENT-FREE; ACID; ALDEHYDES; CATALYST; AMINOPHOSPHONATES;
D O I：
10.1016/j.tetlet.2008.10.106
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Trifluoroethanol is found to be an efficient and recyclable medium in promoting one-pot, three-component coupling reactions of aldehydes or ketones, amines and trimethylsilyl cyanide or trimethyl phosphite to afford the corresponding (alpha-amino nitriles or alpha-amino phosphonates in high yields. This protocol does not require the use of an acid or base catalyst. (C) 2008 Elsevier Ltd. All rights reserved.
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页码：77 / 80
页数：4
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