Bis-esters from maleic anhydrides under neutral conditions: Protection of the anhydride of the natural product cornexistin

被引：9

作者：

Fields, SC

Dent, WH

Green, FR

Tromiczak, EG

机构：

[1] Discovery Research, DowElanco, Dow Venture Center, Indianapolis, IN 46268-1054

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 12期

关键词：

D O I：

10.1016/0040-4039(96)00182-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Trimethylsilyldiazomethane converts maleic anhydride derivatives in alcoholic THF to bis-esters. The highly acid and base sensitive natural product comexistin was converted to its bis-methyl ester in 70-75% yield and to the mixed benzyl/methyl ester in 61% yield. The mixed ester can be converted back to comexistin via transfer hydrogenation.

引用

页码：1967 / 1970

页数：4

共 18 条

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