Chronic traumatic encephalopathy and other neurodegenerative

被引：36

作者：

Tartaglia, Maria Carmela ^{[1
,2
,3
]}

Hazrati, Lili-Naz ^{[2
,3
,4
]}

Davis, Karen D. ^{[3
,5
,6
,7
,8
]}

Green, Robin E. A. ^{[3
,9
]}

Wennberg, Richard ^{[1
,3
]}

Mikulis, David ^{[3
,10
]}

Ezerins, Leo J. ^{[3
,11
]}

Keightley, Michelle ^{[3
,9
,12
,13
,14
,15
,16
]}

Tator, Charles ^{[3
,16
]}

机构：

[1] Toronto Hosp, Univ Hlth Network, Krembil Neurosci Ctr, Div Neurol, Toronto, ON M5T 2S8, Canada

[2] Toronto Hosp, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON M5T 2S8, Canada

[3] Canadian Sports Concussion Project, Toronto, ON, Canada

[4] Toronto Hosp, Dept Lab Med & Pathol, Toronto, ON M5T 2S8, Canada

[5] Toronto Hosp, Univ Hlth Network, Dept Neurosurg, Toronto, ON M5T 2S8, Canada

[6] Univ Hlth Network, Toronto Western Res Inst, Div Brain Imaging & Behav Syst Neurosci, Toronto, ON, Canada

[7] Toronto Hosp, Dept Surg, Toronto, ON M5T 2S8, Canada

[8] Toronto Hosp, Inst Med Sci, Toronto, ON M5T 2S8, Canada

[9] Toronto Rehabil Inst, Toronto, ON, Canada

[10] Toronto Hosp, Joint Dept Med Imaging, Toronto Western Hosp, Div Neuroradiol, Toronto, ON M5T 2S8, Canada

[11] Canadian Football League Alumni Assoc, Toronto, ON, Canada

[12] Holland Bloorview Kids Rehabil Hosp, Bloorview Res Inst, Toronto, ON, Canada

[13] Toronto Hosp, Dept Occupat Sci & Occupat Therapy, Toronto, ON M5T 2S8, Canada

[14] Toronto Hosp, Grad Dept Rehabil Sci, Toronto, ON M5T 2S8, Canada

[15] Toronto Hosp, Dept Psychol, Toronto, ON M5T 2S8, Canada

[16] Toronto Hosp, Krembil Neurosci Ctr, Toronto Western Hosp, Div Neurosurg, Toronto, ON M5T 2S8, Canada

来源：

FRONTIERS IN HUMAN NEUROSCIENCE | 2014年 / 8卷

关键词：

concussions; chronic traumatic encephalopathy; neurodegenerative disease; Alzheimer's disease; frontotempora I lobar degeneration; tau; BRAIN-INJURY; ALZHEIMERS-DISEASE; CEREBROSPINAL-FLUID; UNMYELINATED AXONS; CORPUS-CALLOSUM; HEAD TRAUMA; DEMENTIA; SPORT; BIOMARKERS; FOOTBALL;

D O I：

10.3389/fnhum.2014.00030

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

"Chronic traumatic encephalopathy" (CTE) is described as a slowly progressive neurodegenerative disease believed to result from multiple concussions. Traditionally, concussions were considered benign events and although most people recover fully, about 10% develop a post-concussive syndrome with persisting neurological, cognitive and neuropsychiatric symptoms. CTE was once thought to be unique to boxers, but it has now been observed in many different athletes having suffered multiple concussions as well as in military personal after repeated blast injuries. Much remains unknown about the development of CTE but its pathological substrate is usually tau, similar to that seen in Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD). The aim of this "perspective" is to compare and contrast clinical and pathological CTE with the other neurodegenerative proteinopathies and highlight that there is an urgent need for understanding the relationship between concussion and the development of CTE as it may provide a window into the development of a proteinopathy and thus new avenues for treatment.

引用

页数：6