In vivo production of nitric oxide after administration of cyclohexanone oxime

被引：12

作者：

Glover, RE ^{[1
]}

Corbett, JT ^{[1
]}

Burka, LT ^{[1
]}

Mason, RP ^{[1
]}

机构：

[1] NIEHS, Lab Pharmacol & Chem, NIH, Res Triangle Pk, NC 27709 USA

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 1999年 / 12卷 / 10期

关键词：

D O I：

10.1021/tx990058v

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cyclohexanone oxime (CHOX), an intermediate used in the synthesis of polycaprolactam (Nylon-6), has been reported to be hematotoxic in Fischer rats. The in vivo metabolism of CHOX was found to release nitric oxide, which was detected in venous blood by electron paramagnetic resonance spectroscopy as the nitrosylhemoglobin complex. In vitro incubation of CHOX with venous blood resulted in the formation of the characteristic nitrosylhemoglobin complex, suggesting that the blood was a possible site for metabolism. Excessive nitric oxide production may, in part, contribute to the observed toxicity of CHOX.

引用

页码：952 / 957

页数：6

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