Imaging markers of structural and functional brain changes that precede cognitive symptoms in risk for Alzheimer's disease

被引：29

作者：

Burggren, Alison ^{[1
,3
]}

Brown, Jesse ^{[2
]}

机构：

[1] Univ Calif Los Angeles, Ctr Cognit Neurosci, Semel Neuropsychiat Inst, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA

[2] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA

[3] Univ Calif Los Angeles, Semel Neuropsychiat Inst 17 369, Los Angeles, CA 90095 USA

来源：

BRAIN IMAGING AND BEHAVIOR | 2014年 / 8卷 / 02期

关键词：

Medial temporal lobe; Hippocampus; Magnetic resonance imaging; Diffusion tensor imaging; Functional magnetic resonance imaging; APOE; MEDIAL TEMPORAL-LOBE; WHITE-MATTER INTEGRITY; CORTICAL THICKNESS; OLDER-ADULTS; HIPPOCAMPAL ATROPHY; BETA DEPOSITION; APOE GENOTYPE; FMRI EVIDENCE; GENETIC RISK; MEMORY;

D O I：

10.1007/s11682-013-9278-4

中图分类号：

R445 [影像诊断学];

学科分类号：

100207 ;

摘要：

Neuroimaging has rapidly advanced investigations into dysfunction both within and emanating from the hippocampus in early Alzheimer's disease . Focusing on prodromal subjects, we will discuss structural changes to hippocampal subregions, alterations to functional activity both within the hippocampus and elsewhere in the cortex, as well as changes to structural white matter connectivity and changes to functionally correlated patterns during memory performance. We present ample evidence that asymptomatic subjects demonstrate substantial identifiable brain changes before the onset of cognitive decline, but suggest there is significant work yet to be accomplished before applying these findings to individual patients.

引用

页码：251 / 261

页数：11

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