Opposite Roles of Wnt7a and Sfrp1 in Modulating Proper Development of Neural Progenitors in the Mouse Cerebral Cortex

被引：9

作者：

Miao, Nan ^{[1
,2
]}

Bian, Shan ^{[3
]}

Lee, Trevor ^{[3
]}

Mubarak, Taufif ^{[3
]}

Huang, Shiying ^{[4
]}

Wen, Zhihong ^{[5
,6
]}

Hussain, Ghulam ^{[7
]}

Sun, Tao ^{[1
,2
,3
]}

机构：

[1] Huaqiao Univ, Ctr Precis Med, Sch Med, Xiamen, Peoples R China

[2] Huaqiao Univ, Sch Biomed Sci, Xiamen, Peoples R China

[3] Cornell Univ, Dept Cell & Dev Biol, Weill Cornell Med, New York, NY 10021 USA

[4] Quanzhou Normal Univ, Coll Oceanol & Food Sci, Quanzhou, Peoples R China

[5] Natl Sun Yat Sen Univ, Marine Biomed Lab, Kaohsiung, Taiwan

[6] Natl Sun Yat Sen Univ, Ctr Translat Biopharmaceut, Dept Marine Biotechnol & Resources, Kaohsiung, Taiwan

[7] Govt Coll Univ, Dept Physiol, Faisalabad, Pakistan

来源：

FRONTIERS IN MOLECULAR NEUROSCIENCE | 2018年 / 11卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

Wnt7a; Sfrp1; cerebral cortex; neural progenitors; antagonist; IN-VIVO ELECTROPORATION; PLURIPOTENT STEM-CELLS; NEURONAL DIFFERENTIATION; STEM/PROGENITOR CELLS; ADULT NEUROGENESIS; PRECURSOR CELLS; SELF-RENEWAL; BETA-CATENIN; PATHWAY; CNS;

D O I：

10.3389/fnmol.2018.00247

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The Wingless (Wnt)-mediated signals are involved in many important aspects of development of the mammalian cerebral cortex. How Wnts interact with their modulators in cortical development is still unclear. Here, we show that Wnt7a and secreted frizzled-related protein 1 (Sfrp1), a soluble modulator of Wnts, are co-expressed in mouse embryonic cortical neural progenitors (NPs). Knockout of Wnt7a in mice causes microcephaly due to reduced NP population and neurogenesis, and Sfrp1 has an opposing effect compared to Wnt7a. Similar to Dkk1, Sfrp1 decreases the Wnt1 and Wnt7a activity in vitro. Our results suggest that Wnt7a and Sfrp1 play opposite roles to ensure proper NP progeny in the developing cortex.

引用

页数：14

共 7 条

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