Transient left ventricular apical ballooning in a community hospital in Germany

Introduction: Tako-tsubo cardiomyopathy represents an intermittent left ventricular dysfunction with a ballooning of the left ventricular apical myocardium without significant coronary artery disease. Precise epidemiological data are not yet available. Methods and results: We retrospectively reviewed 16,989 cases with diagnostic angiographies in our catheter laboratory from January 2001 until December 2004 for intermittent left ventricular apical ballooning. Thirty-two (0.2%) patients were included (50% of all cases presented in 2004, 50% of all cases during the summer months). Twenty-nine (91%) were female, median age was 67.5 years. Fourteen patients (44%) were known to have chronic obstructive pulmonary disease or asthma. Thirteen patients (41%) reported an acute stressful event prior to onset of symptoms. Twenty-five (78%) of the patients presented with clinical signs of an acute coronary syndrome with positive troponin T in 20 (63%) patients. Median left ventricular ejection fraction was 42.5%. Follow-up data of 30 patients (94%) could be obtained; median follow-up time is 6 months. Two patients died during follow-up (malignancy; unknown cause). Echocardiography was performed in 26 (81%) patients; median ejection fraction was 70%. Conclusion: Tako-tsubo-like cardiomyopathy might be considered a differential diagnosis for acute coronary syndrome especially in elderly women. Chronic pulmonary diseases may be associated with a higher risk. The reason for the increasing number of cases during the last year is not clear; however, the tendency for early angiography in acute coronary syndrome may have contributed. The reason for the accumulation of cases during the summer months is also not yet understood. (c) 2005 Elsevier Ireland Ltd. All rights reserved.