Potential of the Electronic Nose for the Detection of Respiratory Diseases with and without Infection

被引：38

作者：

Licht, Johann-Christoph ^{[1
,2
,3
]}

Grasemann, Hartmut ^{[1
,2
]}

机构：

[1] Hosp Sick Children, Div Resp Med, Dept Pediat, Toronto, ON M5G 1X8, Canada

[2] Hosp Sick Children Res Inst, Translat Med Res Program, Toronto, ON M5G 1X8, Canada

[3] Univ Toronto, Dept Immunol, Toronto, ON M5S 1A8, Canada

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 24期

关键词：

electronic nose; respiratory disease; respiratory infections; volatile organic compounds; VOLATILE ORGANIC-COMPOUNDS; PSEUDOMONAS-AERUGINOSA COLONIZATION; OBSTRUCTIVE PULMONARY-DISEASE; PRIMARY CILIARY DYSKINESIA; CELL LUNG-CANCER; CYSTIC-FIBROSIS; EXHALED BREATH; AIRWAY INFLAMMATION; NITRIC-OXIDE; DISCRIMINATION;

D O I：

10.3390/ijms21249416

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Respiratory tract infections are common, and when affecting the lower airways and lungs, can result in significant morbidity and mortality. There is an unfilled need for simple, non-invasive tools that can be used to screen for such infections at the clinical point of care. The electronic nose (eNose) is a novel technology that detects volatile organic compounds (VOCs). Early studies have shown that certain diseases and infections can result in characteristic changes in VOC profiles in the exhaled breath. This review summarizes current knowledge on breath analysis by the electronic nose and its potential for the detection of respiratory diseases with and without infection.

引用

页码：1 / 16

页数：16

共 89 条

[1] Non-invasive exhaled volatile organic biomarker analysis to detect inflammatory bowel disease (IBD) [J].

Arasaradnam, Ramesh P. ;

McFarlane, Michael ;

Daulton, Emma ;

Skinner, Jim ;

O'Connell, Nicola ;

Wurie, Subiatu ;

Chambers, Samantha ;

Nwokolo, Chuka ;

Bardhan, Karna ;

Savage, Richard ;

Covington, James .

DIGESTIVE AND LIVER DISEASE, 2016, 48 (02) :148-153

[2] Detection of Colorectal Cancer (CRC) by Urinary Volatile Organic Compound Analysis [J].

Arasaradnam, Ramesh P. ;

McFarlane, Michael J. ;

Ryan-Fisher, Courtenay ;

Westenbrink, Erik ;

Hodges, Paula ;

Thomas, Matthew G. ;

Chambers, Samantha ;

O'Connell, Nicola ;

Bailey, Catherine ;

Harmston, Christopher ;

Nwokolo, Chuka U. ;

Bardhan, Karna D. ;

Covington, James A. .

PLOS ONE, 2014, 9 (09)

[3] Feasibility and diagnostic accuracy of an electronic nose in children with asthma and cystic fibrosis [J].

Bannier, Michiel A. G. E. ;

van de Kant, Kim D. G. ;

Jobsis, Quirijn ;

Dompeling, Edward .

JOURNAL OF BREATH RESEARCH, 2019, 13 (03)

[4] Electronic nose: a non-invasive technology for breath analysis of diabetes and lung cancer patients [J].

Behera, Bhagaban ;

Joshi, Rathin ;

Vishnu, G. K. Anil ;

Bhalerao, Sanjay ;

Pandya, Hardik J. .

JOURNAL OF BREATH RESEARCH, 2019, 13 (02)

[5] Alterations in exhaled breath metabolite-mixtures in two rat models of lipopolysaccharide-induced lung injury [J].

Bos, Lieuwe D. J. ;

van Walree, Inez C. ;

Kolk, Arend H. J. ;

Janssen, Hans-Gerd ;

Sterk, Peter J. ;

Schultz, Marcus J. .

JOURNAL OF APPLIED PHYSIOLOGY, 2013, 115 (10) :1487-1495

[6] Volatile Metabolites of Pathogens: A Systematic Review [J].

Bos, Lieuwe D. J. ;

Sterk, Peter J. ;

Schultz, Marcus J. .

PLOS PATHOGENS, 2013, 9 (05)

[7] Partial least squares discriminant analysis: taking the magic away [J].

Brereton, Richard G. ;

Lloyd, Gavin R. .

JOURNAL OF CHEMOMETRICS, 2014, 28 (04) :213-225

[8] Exhaled breath profiles in the monitoring of loss of control and clinical recovery in asthma [J].

Brinkman, P. ;

van de Pol, M. A. ;

Gerritsen, M. G. ;

Bos, L. D. ;

Dekker, T. ;

Smids, B. S. ;

Sinha, A. ;

Majoor, C. J. ;

Sneeboer, M. M. ;

Knobel, H. H. ;

Vink, T. J. ;

de Jongh, F. H. ;

Lutter, R. ;

Sterk, P. J. ;

Fens, N. .

CLINICAL AND EXPERIMENTAL ALLERGY, 2017, 47 (09) :1159-1169

[9] Identification and prospective stability of electronic nose (eNose)-derived inflammatory phenotypes in patients with severe asthma [J].

Brinkman, Paul ;

Wagener, Ariane H. ;

Hekking, Pieter-Paul ;

Bansal, Aruna T. ;

Maitland-van der Zee, Anke-Hilse ;

Wang, Yuanyue ;

Weda, Hans ;

Knobel, Hugo H. ;

Vink, Teunis J. ;

Rattray, Nicholas J. ;

D'Amico, Arnaldo ;

Pennazza, Giorgio ;

Santonico, Marco ;

Lefaudeux, Diane ;

De Meulder, Bertrand ;

Auffray, Charles ;

Bakke, Per S. ;

Caruso, Massimo ;

Chanez, Pascal ;

Chung, Kian F. ;

Corfield, Julie ;

Dahlen, Sven-Erik ;

Djukanovic, Ratko ;

Geiser, Thomas ;

Horvath, Ildiko ;

Krug, Nobert ;

Musial, Jacek ;

Sun, Kai ;

Riley, John H. ;

Shaw, Dominic E. ;

Sandstrom, Thomas ;

Sousa, Ana R. ;

Montuschi, Paolo ;

Fowler, Stephen J. ;

Sterk, Peter J. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2019, 143 (05) :1811-+

[10] Diagnosis of active tuberculosis by e-nose analysis of exhaled air [J].

Bruins, Marcel ;

Rahim, Zeaur ;

Bos, Albert ;

van de Sande, Wendy W. J. ;

Endtz, Hubert Ph. ;

van Belkum, Alex .

TUBERCULOSIS, 2013, 93 (02) :232-238

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