Ion Channels and Transporters in Inflammation: Special Focus on TRP Channels and TRPC6

被引:45
|
作者
Ramirez, Giuseppe A. [1 ,2 ,3 ]
Coletto, Lavinia A. [1 ,2 ,3 ]
Sciorati, Clara [1 ,3 ]
Bozzolo, Enrica P. [1 ,2 ]
Manunta, Paolo [1 ,4 ]
Rovere-Querini, Patrizia [1 ,2 ,3 ]
Manfredi, Angelo A. [1 ,2 ,3 ]
机构
[1] Univ Vita Salute San Raffaele, Unit Immunol Rheumatol Allergy & Rare Dis, I-20132 Milan, Italy
[2] IRCCS Osped San Raffaele, Unit Immunol Rheumatol Allergy & Rare Dis, I-20132 Milan, Italy
[3] IRCCS Osped San Raffaele, Div Immunol Transplantat & Infect Immun, I-20132 Milan, Italy
[4] IRCCS Osped San Raffaele, Unit Nephrol, I-20132 Milan, Italy
关键词
TRPC6; elementary immunology; inflammation; calcium; sodium; neutrophils; lymphocytes; endothelium; platelets; SYSTEMIC-LUPUS-ERYTHEMATOSUS; OPERATED CA2+ ENTRY; ISCHEMIA-REPERFUSION INJURY; ARTERIAL SMOOTH-MUSCLE; POTENTIAL CANONICAL 6; GATED SODIUM-CHANNEL; CALCIUM-ENTRY; T-LYMPHOCYTE; MEDIATED INHIBITION; CYTOKINE PRODUCTION;
D O I
10.3390/cells7070070
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Allergy and autoimmune diseases are characterised by a multifactorial pathogenic background. Several genes involved in the control of innate and adaptive immunity have been associated with diseases and variably combine with each other as well as with environmental factors and epigenetic processes to shape the characteristics of individual manifestations. Systemic or local perturbations in salt/water balance and in ion exchanges between the intra- and extracellular spaces or among tissues play a role. In this field, usually referred to as elementary immunology, novel evidence has been recently acquired on the role of members of the transient potential receptor (TRP) channel family in several cellular mechanisms of potential significance for the pathophysiology of the immune response. TRP canonical channel 6 (TRPC6) is emerging as a functional element for the control of calcium currents in immune-committed cells and target tissues. In fact, TRPC6 influences leukocytes' tasks such as transendothelial migration, chemotaxis, phagocytosis and cytokine release. TRPC6 also modulates the sensitivity of immune cells to apoptosis and influences tissue susceptibility to ischemia-reperfusion injury and excitotoxicity. Here, we provide a view of the interactions between ion exchanges and inflammation with a focus on the pathogenesis of immune-mediated diseases and potential future therapeutic implications.
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页数:24
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