Refocusing on BRCA1

被引：8

作者：

Ashworth, A ^{[1
]}

机构：

[1] Inst Canc Res, Breakthrough Breast Canc Res Ctr, London SW3 6JB, England

来源：

NATURE CELL BIOLOGY | 2004年 / 6卷 / 10期

关键词：

D O I：

10.1038/ncb1004-916

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A panoply of functions have been proposed for the BRCA1 cancer susceptibility protein, particularly in the response to DNA damage and in transcriptional regulation. This complexity is now exacerbated by the discovery of a distinct splice variant of BRCA1, BRCA1/IRIS, with a previously uncharacterized function in DNA replication. This has implications for understanding tumorigenesis in BRCA1 mutation carriers.

引用

页码：916 / 917

页数：2

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