Refocusing on BRCA1

被引：8

作者：

Ashworth, A ^{[1
]}

机构：

[1] Inst Canc Res, Breakthrough Breast Canc Res Ctr, London SW3 6JB, England

来源：

NATURE CELL BIOLOGY | 2004年 / 6卷 / 10期

关键词：

D O I：

10.1038/ncb1004-916

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A panoply of functions have been proposed for the BRCA1 cancer susceptibility protein, particularly in the response to DNA damage and in transcriptional regulation. This complexity is now exacerbated by the discovery of a distinct splice variant of BRCA1, BRCA1/IRIS, with a previously uncharacterized function in DNA replication. This has implications for understanding tumorigenesis in BRCA1 mutation carriers.

引用

页码：916 / 917

页数：2

共 14 条

[1] Identification of BRCA1-IRIS, a BRCA1 locus product [J].

ElShamy, WM ;

Livingston, DM .

NATURE CELL BIOLOGY, 2004, 6 (10) :954-+

[2] GERMLINE MUTATIONS OF THE BRCA1 GENE IN BREAST AND OVARIAN-CANCER FAMILIES PROVIDE EVIDENCE FOR A GENOTYPE-PHENOTYPE CORRELATION [J].

GAYTHER, SA ;

WARREN, W ;

MAZOYER, S ;

RUSSELL, PA ;

HARRINGTON, PA ;

CHIANO, M ;

SEAL, S ;

HAMOUDI, R ;

VANRENSBURG, EJ ;

DUNNING, AM ;

LOVE, R ;

EVANS, G ;

EASTON, D ;

CLAYTON, D ;

STRATTON, MR ;

PONDER, BAJ .

NATURE GENETICS, 1995, 11 (04) :428-433

[3] Estimating rates of alternative splicing in mammals and invertebrates - Reply [J].

Harrington, ED ;

Boue, S ;

Valcarcel, J ;

Reich, JG ;

Bork, P .

NATURE GENETICS, 2004, 36 (09) :916-917

[4] Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays [J].

Johnson, JM ;

Castle, J ;

Garrett-Engele, P ;

Kan, ZY ;

Loerch, PM ;

Armour, CD ;

Santos, R ;

Schadt, EE ;

Stoughton, R ;

Shoemaker, DD .

SCIENCE, 2003, 302 (5653) :2141-2144

[5] Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development [J].

Joukov, V ;

Chen, J ;

Fox, EA ;

Green, JBA ;

Livingston, DM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (21) :12078-12083

[6] New complexities for BRCA1 and BRCA2 [J].

Kerr, P ;

Ashworth, A .

CURRENT BIOLOGY, 2001, 11 (16) :R668-R676

[7] Estimating rates of alternative splicing in mammals and invertebrates [J].

Kim, H ;

Klein, R ;

Majewski, J ;

Ott, J .

NATURE GENETICS, 2004, 36 (09) :915-916

[8] BRCT repeats as phosphopeptide-binding modules involved in protein targeting [J].

Manke, IA ;

Lowery, DM ;

Nguyen, A ;

Yaffe, MB .

SCIENCE, 2003, 302 (5645) :636-639

[9] BRCA1 and BRCA2:: 1994 and beyond [J].

Narod, SA ;

Foulkes, WD .

NATURE REVIEWS CANCER, 2004, 4 (09) :665-676

[10] Control of DNA replication licensing in a cell cycle [J].

Nishitani, H ;

Lygerou, Z .

GENES TO CELLS, 2002, 7 (06) :523-534

← 1 2 →