Biocatalysis in development of green pharmaceutical processes

被引：202

作者：

Tao, Junhua ^{[1
]}

Xu, Jian-He ^{[2
]}

机构：

[1] Elevance Renewable Sci Inc, Bolingbrook, IL 60440 USA

[2] E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2009年 / 13卷 / 01期

关键词：

ENANTIOSELECTIVE SYNTHESIS; CHEMOENZYMATIC SYNTHESIS; SIDE-CHAIN; EFFICIENT;

D O I：

10.1016/j.cbpa.2009.01.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biocatalysis is one of the greenest technologies for the synthesis of chiral molecules due to exquisite regioselectivity and stereoselectivity in water under mild conditions. For example, protection and deprotection of functional groups are usually not required for biotransformations, high or low temperature reactions can often be circumvented and usage of organic solvents are drastically minimized. To truly empower the green chemistry feature of biocatalysis, it is essential to integrate enzymatic transformations strategically into chemical transformations at the retrosynthetic level. This review focuses on the development of novel biocatalytic pharmaceutical processes to replace chemical routes with poorer process efficiency and higher manufacturing costs.

引用

页码：43 / 50

页数：8

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