Links between innate and adaptive immunity via type I interferon

被引：494

作者：

Le Bon, A ^{[1
]}

Tough, DF ^{[1
]}

机构：

[1] Edward Jenner Inst Vaccine Res, Newbury RG20 7NN, Berks, England

来源：

CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(02)00354-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Type I interferon (IFN-alpha/beta) is expressed rapidly following exposure to a wide variety of infectious agents and plays a key role in innate control of virus replication. Recent studies have demonstrated that dendritic cells both produce IFN-alpha/beta and undergo maturation in response to IFN-alpha/beta. Moreover, IFN-alpha/beta has been shown to potently enhance immune responses in vivo through the stimulation of dendritic cells. These findings indicate that IFN-alpha/beta serves as a signal linking innate and adaptive immunity.

引用

页码：432 / 436

页数：5

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