Histone deacetylase inhibitor sodium butyrate promotes the osteogenic differentiation of rat adipose- derived stem cells

被引：22
|
作者：
Hu, Xiaoqing [1 ]
Fu, Yutuo [2 ]
Zhang, Xin [1 ]
Dai, Linghui [1 ]
Zhu, Jingxian [1 ]
Bi, Zhenggang [2 ]
Ao, Yingfang [1 ]
Zhou, Chunyan [3 ]
机构：
[1] Peking Univ, Inst Sports Med, Hosp 3, Beijing 100191, Peoples R China
[2] Harbin Med Univ, Affiliated Hosp 1, Dept Orthoped, Harbin 150001, Peoples R China
[3] Peking Univ, Dept Biochem & Mol Biol, Sch Basic Med Sci, Beijing 100191, Peoples R China
来源：
DEVELOPMENT GROWTH & DIFFERENTIATION | 2014年 / 56卷 / 03期
基金：
中国博士后科学基金;
关键词：
adipose derived stem cells; epigenetic regulation; histone deacetylase inhibitor; osteogenic differentiation; sodium butyrate; IN-VITRO; RUNX2/CBFA1; EXPRESSION; TISSUE; BONE;
D O I：
10.1111/dgd.12119
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Adult stem cells hold great promise for use in tissue repair and regeneration. Recently, adipose tissue-derived stem cells (ADSCs) were found to be an appealing alternative to bone marrow stem cells (BMSCs) for bone tissue engineering. The main benefit of ADSCs is that they can be easily and abundantly available from adipose tissue. However, our prior study discovered an important phenomenon that BMSCs have greater osteogenic potential than ADSCs in vitro and epigenetic regulation plays a critical role in runt-related transcription factor 2 (Runx2) expression and thus osteogenesis. In this study, we aimed to improve the osteogenic potential of ADSCs by histone deacetylase inhibitor sodium butyrate (NaBu). We found that NaBu promoted rat ADSC osteogenic differentiation by altering the epigenetic modifications on the Runx2 promoter.
引用
收藏
页码：206 / 213
页数：8
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