Phase-Separation-Induced Formation of Janus Droplets Based on Aqueous Two-Phase Systems

被引：48

作者：

Yuan, Hao ^{[1
,2
]}

Ma, Qingming ^{[1
,2
]}

Song, Yang ^{[1
,2
]}

Tang, Matthew Y. H. ^{[1
,2
]}

Chan, Yau Kei ^{[1
,2
]}

Shum, Ho Cheung ^{[1
,2
]}

机构：

[1] Univ Hong Kong, Dept Mech Engn, Pokfulam Rd, Hong Kong, Hong Kong, Peoples R China

[2] HKU SIRI, Shenzhen 518000, Peoples R China

来源：

MACROMOLECULAR CHEMISTRY AND PHYSICS | 2017年 / 218卷 / 02期

基金：

中国国家自然科学基金;

关键词：

aqueous two-phase system; bioactivity preservation; droplet microfluidics; phase separation; ORDER MULTIPLE EMULSIONS; POLYMER BLENDS; MICROFLUIDIC FABRICATION; TRANSGENIC MICE; PARTICLES; NANOPARTICLES; MICROPARTICLES; TUMORS;

D O I：

10.1002/macp.201600422

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

In this study, Janus droplets are fabricated by inducing phase separation of single-phase droplets made up of an aqueous two-phase system (ATPS). The resultant Janus droplets are highly monodisperse in structures and internal morphologies. Due to the affinity partitioning properties of ATPS, encapsulated ingredients can automatically partition into different compartments of the resultant Janus droplets. The use of biocompatible and cytocompatible ATPS also enables the encapsulation of enzymes and cells in the resultant droplets with their activity preserved at a relatively high level.

引用

页数：8

共 47 条

[1] High-Order Multiple Emulsions Formed in Poly(dimethylsiloxane) Microfluidics [J].

Abate, A. R. ;

Weitz, D. A. .

SMALL, 2009, 5 (18) :2030-2032

[2] BILATERAL RETINAL AND BRAIN-TUMORS IN TRANSGENIC MICE EXPRESSING SIMIAN VIRUS-40 LARGE T-ANTIGEN UNDER CONTROL OF THE HUMAN INTERPHOTORECEPTOR RETINOID-BINDING PROTEIN PROMOTER [J].

ALUBAIDI, MR ;

FONT, RL ;

QUIAMBAO, AB ;

KEENER, MJ ;

LIOU, GI ;

OVERBEEK, PA ;

BAEHR, W .

JOURNAL OF CELL BIOLOGY, 1992, 119 (06) :1681-1687

[3]

[Anonymous], 2000, AQUEOUS 2 PHASE SYST

[4] One-step fabrication of polymeric hybrid particles with core-shell, patchy, patchy Janus and Janus architectures via a microfluidic-assisted phase separation process [J].

Cao, Xiaodong ;

Li, Wenxiu ;

Ma, Ting ;

Dong, Hua .

RSC ADVANCES, 2015, 5 (97) :79969-79975

[5] Co-axial capillaries microfluidic device for synthesizing size- and morphology-controlled polymer core-polymer shell particles [J].

Chang, Zhenqi ;

Serra, Christophe A. ;

Bouquey, Michel ;

Prat, Laurent ;

Hadziioannou, Georges .

LAB ON A CHIP, 2009, 9 (20) :3007-3011

[6] Enhancing Protease Activity Assay in Droplet-Based Microfluidics Using a Biomolecule Concentrator [J].

Chen, Chia-Hung ;

Sarkar, Aniruddh ;

Song, Yong-Ak ;

Miller, Miles A. ;

Kim, Sung Jae ;

Griffith, Linda G. ;

Lauffenburger, Douglas A. ;

Han, Jongyoon .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (27) :10368-10371

[7] Janus Particles Templated from Double Emulsion Droplets Generated Using Mcrofluidics [J].

Chen, Chia-Hung ;

Shah, Rhutesh K. ;

Abate, Adam R. ;

Weitz, David A. .

LANGMUIR, 2009, 25 (08) :4320-4323

[8] One-step production of multiple emulsions: microfluidic, polymer-stabilized and particle-stabilized approaches [J].

Clegg, Paul S. ;

Tavacoli, Joe W. ;

Wilde, Pete J. .

SOFT MATTER, 2016, 12 (04) :998-1008

[9]

Forrest JA, 1996, J POLYM SCI POL PHYS, V34, P3009, DOI 10.1002/(SICI)1099-0488(199612)34:17<3009::AID-POLB13>3.0.CO

[10]

2-B

← 1 2 3 4 5 →