Interleukin 10 expression is related to aggressiveness and poor prognosis of patients with thyroid cancer

被引:39
作者
Cunha, Lucas Leite [1 ]
Morari, Elaine Cristina [1 ,2 ]
Nonogaki, Sueli [3 ]
Marcello, Marjory Alana [1 ]
Soares, Fernando Augusto [4 ]
Vassallo, Jose [4 ,5 ]
Ward, Laura Sterian [1 ]
机构
[1] Univ Campinas Unicamp, Fac Med Sci, Lab Canc Mol Genet, 126 Tessalia Veira de Camargo St,Cidade Univ, BR-11083894 Sao Paulo, Brazil
[2] State Univ Roraima, Dept Biol & Hlth Sci, Boa Vista, Brazil
[3] Adolfo Lutz Inst, Sao Paulo, Brazil
[4] AC Camargo Canc Ctr, Dept Pathol, Sao Paulo, Brazil
[5] Univ Campinas Unicamp, Fac Med Sci, Lab Investigat & Mol Pathol Ciped, Campinas, SP, Brazil
基金
巴西圣保罗研究基金会;
关键词
Thyroid neoplasm; Tumor immunology; Interleukin; 10; Prognostic marker; AUTOCRINE PRODUCTION; CLINICAL STAGE; CLASS-I; IL-10; CARCINOMAS; CYTOKINES; SURVIVAL; GROWTH;
D O I
10.1007/s00262-016-1924-4
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Most patients with thyroid cancer will evolve very well with current therapies. However, 10-30% of these patients will present recurrent disease and some of them will eventually die. IL-10 is an anti-inflammatory and immunosuppressive cytokine that can contribute to the immune escape of neoplastic cells. We aimed to investigate IL-10 as a molecular marker to improve the clinical management of patients with thyroid cancer. We retrospectively studied 162 patients with follicular cell-derived thyroid cancer who attended to our institution, including 63 classic papillary thyroid carcinomas, 46 follicular variant of papillary thyroid carcinomas, 11 poorly differentiated thyroid carcinomas and 42 follicular thyroid carcinomas. Patients were treated according to current guidelines and followed-up for 1-150 months. Additionally, we studied 96 samples of non-malignant tissues. We investigated the expression of IL-10 in tumor cells by semiquantitative and quantitative methods. Malignant tissues presented higher positivity (0.773 +/- 0.140) than non-malignant samples (0.623 +/- 0.190; p < 0.001). Tumors with extrathyroidal invasion at diagnosis presented higher levels of positivity for IL-10 (0.802 +/- 0.125) than tumors without extrathyroidal invasion (0.731 +/- 0.147; p = 0.004). We observed a positive correlation between tumor size and IL-10 positivity (correlation coefficient = 0.407; p < 0.001). Patients with IL-10 positivity above the median presented lower relapse-free survival rate compared to those patients whose tumors presented IL-10 positivity below the median. We suggest that a simple IL-10 IHC analysis could help selecting patients who would benefit from a more intensive approach.
引用
收藏
页码:141 / 148
页数:8
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