Increased herpes zoster risk associated with poor HLA-A immediate early 62 protein (IE62) affinity

被引：7

作者：

Meysman, Pieter ^{[1
,2
,3
]}

De Neuter, Nicolas ^{[1
,2
,3
]}

Bartholomeus, Esther ^{[3
,4
,5
]}

Elias, George ^{[3
,6
,7
]}

Van den Bergh, Johan ^{[6
]}

Emonds, Marie-Paule ^{[8
]}

Haasnoot, Geert W. ^{[9
]}

Heynderickx, Steven ^{[6
,7
]}

Wens, Johan ^{[10
]}

Michels, Nele R. ^{[10
]}

Lambert, Julien ^{[11
]}

Lion, Eva ^{[6
,7
]}

Claas, Frans H. J. ^{[9
]}

Goossens, Herman ^{[12
,13
]}

Smits, Evelien ^{[3
,6
,7
,14
]}

Van Damme, Pierre ^{[15
]}

Van Tendeloo, Viggo ^{[3
,6
]}

Beutels, Philippe ^{[3
,16
,17
]}

Suls, Arvid ^{[3
,4
,5
]}

Mortier, Geert ^{[3
,4
,5
]}

Laukens, Kris ^{[1
,2
,3
]}

Ogunjimi, Benson ^{[3
,6
,16
,18
,19
]}

机构：

[1] Univ Antwerp, ADREM Data Lab, Dept Math & Comp Sci, B-2020 Antwerp, Belgium

[2] Univ Antwerp, Biomed Informat Res Network Antwerp Biomina, B-2020 Antwerp, Belgium

[3] Univ Antwerp, Antwerp Unit Data Anal & Computat Immunol & Seque, B-2020 Antwerp, Belgium

[4] Antwerp Univ Hosp, Ctr Med Genet, B-2650 Edegem, Belgium

[5] Univ Antwerp, Ctr Med Genet, B-2650 Edegem, Belgium

[6] Univ Antwerp, Vaccine & Infect Dis Inst VAXINFECTIO, Lab Expt Hematol, B-2650 Antwerp, Belgium

[7] Antwerp Univ Hosp, Ctr Cell Therapy & Regenerat Med, B-2650 Edegem, Belgium

[8] Red Cross Flanders, Lab Histocompatibil & Immunogenet HILA, B-2800 Mechelen, Belgium

[9] Leiden Univ, Dept Immunohaematol & Blood Transfus, Med Ctr, NL-2300 Leiden, Netherlands

[10] Univ Antwerp, Dept Primary & Interdisciplinary Care, B-2610 Antwerp, Belgium

[11] Univ Antwerp, Dept Dermatol, Antwerp Univ Hosp, B-2650 Edegem, Belgium

[12] Antwerp Univ Hosp, Dept Lab Med, B-2650 Edegem, Belgium

[13] Univ Antwerp, Vaccine & Infect Dis Inst VAXINFECTIO, Lab Med Microbiol, B-2610 Antwerp, Belgium

[14] Univ Antwerp, Ctr Oncol Res Antwerp, B-2610 Antwerp, Belgium

[15] Univ Antwerp, Vaccine & Infect Dis Inst VAXINFECTIO, Ctr Evaluat Vaccinat, B-2610 Antwerp, Belgium

[16] Univ Antwerp, Vaccine & Infect Dis Inst VAXINFECTIO, Ctr Hlth Econ Res & Modeling Infect Dis, B-2610 Antwerp, Belgium

[17] Univ New South Wales, Sch Publ Hlth & Community Med, Sydney, NSW 2052, Australia

[18] Ghent Univ Hosp, Dept Paediat Nephrol & Rheumatol, B-9000 Ghent, Belgium

[19] Antwerp Univ Hosp, Dept Paediat, B-2650 Edegem, Belgium

来源：

IMMUNOGENETICS | 2018年 / 70卷 / 06期

关键词：

Varicella zoster virus; Herpes zoster; HLA association; MHC peptide affinity; POSTHERPETIC NEURALGIA; IMMUNE-RESPONSES; VIRUS; SUSCEPTIBILITY; IDENTIFICATION; PROMOTER; TEGUMENT; COMPLEX; VACCINE; HEALTH;

D O I：

10.1007/s00251-017-1047-x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Around 30% of individuals will develop herpes zoster (HZ), caused by the varicella zoster virus (VZV), during their life. While several risk factors for HZ, such as immunosuppressive therapy, are well known, the genetic and molecular components that determine the risk of otherwise healthy individuals to develop HZ are still poorly understood. We created a computational model for the Human Leukocyte Antigen (HLA-A, -B, and -C) presentation capacity of peptides derived from the VZV Immediate Early 62 (IE62) protein. This model could then be applied to a HZ cohort with known HLA molecules. We found that HLA-A molecules with poor VZV IE62 presentation capabilities were more common in a cohort of 50 individuals with a history of HZ compared to a nationwide control group, which equated to a HZ risk increase of 60%. This tendency was most pronounced for cases of HZ at a young age, where other risk factors are less prevalent. These findings provide new molecular insights into the development of HZ and reveal a genetic predisposition in those individuals most at risk to develop HZ.

引用

页码：363 / 372

页数：10

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