Assignment of Alzheimer's presenilin-2 (PS-2) gene to 1q42.1 by fluorescence in situ hybridization

被引：5

作者：

Takano, T

Sahara, N

Yamanouchi, Y

Mori, H

机构：

[1] PSYCHIAT RES INST TOKYO,DEPT MOL BIOL,SETAGAYA KU,TOKYO 156,JAPAN

[2] TEIKYO UNIV,SCH MED,DEPT HYG & PUBL HLTH,ITABASHI KU,TOKYO 173,JAPAN

来源：

NEUROSCIENCE LETTERS | 1997年 / 221卷 / 2-3期

关键词：

Alzheimer's disease; presenilin-2; chromosome; 1; fluorescence in situ hybridization; Volga-German;

D O I：

10.1016/S0304-3940(96)13290-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Presenilin-2 (PS-2) was suggested to be localized on 1q31-42 based on linkage analysis and cDNA cloning. The final identification of PS-2 as the causal gene for early-onset familial Alzheimer's disease in Voga-German pedigrees was concluded based on the point mutation found in the candidate cDNA isolated from this familial AD. We present evidence of its physical genome mapping of PS-2 on chromosome 1q42.1 by fluorescence in situ hybridization method. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：205 / 207

页数：3

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