Assignment of Alzheimer's presenilin-2 (PS-2) gene to 1q42.1 by fluorescence in situ hybridization

被引：5
|
作者：
Takano, T
Sahara, N
Yamanouchi, Y
Mori, H
机构：
[1] PSYCHIAT RES INST TOKYO,DEPT MOL BIOL,SETAGAYA KU,TOKYO 156,JAPAN
[2] TEIKYO UNIV,SCH MED,DEPT HYG & PUBL HLTH,ITABASHI KU,TOKYO 173,JAPAN
来源：
NEUROSCIENCE LETTERS | 1997年 / 221卷 / 2-3期
关键词：
Alzheimer's disease; presenilin-2; chromosome; 1; fluorescence in situ hybridization; Volga-German;
D O I：
10.1016/S0304-3940(96)13290-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Presenilin-2 (PS-2) was suggested to be localized on 1q31-42 based on linkage analysis and cDNA cloning. The final identification of PS-2 as the causal gene for early-onset familial Alzheimer's disease in Voga-German pedigrees was concluded based on the point mutation found in the candidate cDNA isolated from this familial AD. We present evidence of its physical genome mapping of PS-2 on chromosome 1q42.1 by fluorescence in situ hybridization method. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码：205 / 207
页数：3
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