A novel missense mutation C11994T in the mitochondrial ND4 gene as a cause of low sperm motility in the Indian subcontinent

被引：66

作者：

Rani, Deepa Selvi

Vanniarajan, Ayyasamy

Gupta, Nalini J.

Chakravarty, Baidyanath

Singh, Lalji

Thangaraj, Kumarasamy

机构：

[1] Ctr Cellular & Mol Biol, Evolutionary & Med Genet Lab, Hyderabad 500007, Andhra Pradesh, India

[2] Inst Reprod Med, Kolkata, W Bengal, India

来源：

FERTILITY AND STERILITY | 2006年 / 86卷 / 06期

关键词：

D O I：

10.1016/j.fertnstert.2006.04.044

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

We have analyzed the mitochondrial DNA of 34 oligoasthenozoospermic men along with 150 normozoospermic fertile men from the Indian subcontinent. A novel missense mutation (C11994T) in the ND4 gene, which replaces threonine with isoleucine, was observed in all of the oligoasthenozoospermic men but not in any of the normozoospermic fertile men.

引用

页码：1783 / 1785

页数：3

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