Dietary sorbose ameliorates obesity and hyperglycemia in gold thioglucose-injected obese mice

The influence of dietary sorbose on hyperphagia, hyperglycemia and hyperinsulinemia in gold thioglucose (GTG)-injected obese mice was examined. Body weight of GTG-injected obese mice was decreased by feeding a sorbose diet. When GTG-injected obese mice were given the diet containing sorbose, food intake was significantly lower than that of intact normal mice given a sucrose diet. The reduction in body weight of GTG-injected obese mice given dietary sorbose may be due to the decrease in food intake. Blood glucose concentration in GTG-injected obese mice was decreased by feeding the sorbose diet to the level of intact normal mice given sucrose. Feeding the sorbose diet lowered plasma insulin concentration compared to the sucrose group. It is concluded that feeding sorbose ameliorates hyperphagia, hyperglycemia and hyperinsulinemia in GTG-injected obese mice.