Immunomodulatory neural stem cells for brain tumour therapy

被引：17

作者：

Yu, Jeffrey J. ^{[1
]}

Sun, Xiaonan ^{[1
]}

Yuan, Xiangpeng ^{[1
]}

Lee, Jang-Won ^{[1
]}

Snyder, Evan Y. ^{[1
]}

Yu, John S. ^{[1
]}

机构：

[1] Cedars Sinai Med Ctr, Dept Neurosurg, Los Angeles, CA 90048 USA

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2006年 / 6卷 / 12期

关键词：

bone marrow-derived stem cells; brain tumour; IL-12; IL-23; IL-27; neural stem cell;

D O I：

10.1517/14712598.6.12.1255

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Advances in the understanding of stem cells have enabled the development of novel therapies for brain tumours. Neural stem cells (NSCs) possess the ability to migrate throughout the CNS. By exploiting the tropism of NSCs to various neural pathologies (e.g., glioma, degeneration, stroke and so on) and the delivery of various immunomodulatory cytokines, new treatments for brain tumours have been investigated. These new strategies offer significantly more specificity than existing treatment regimens, such as surgery, radiation and chemotherapy. As methods in isolating and culturing NSCs are better understood, clinical applications of this therapeutic strategy may inevitably emerge. Here, the preclinical advances and the results supporting the effectiveness of stem cell therapies are reviewed. In addition, the obstacles to clinical development and methods to circumvent these caveats are discussed.

引用

页码：1255 / 1262

页数：8

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