Improved compression properties of propyphenazone spherical crystals

被引：27

作者：

Di Martino, P

Di Cristofaro, R

Barthélémy, C

Joiris, E

Filippo, GP

Sante, M

机构：

[1] Fac Farm, Dipartimento Sci Chim, Lab Tecn Farmaceut, I-62032 Camerino, Italy

[2] Univ Lille 2, Fac Sci Pharmaceut & Biol, Lab Pharmacotech Off & Ind, F-59006 Lille, France

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2000年 / 197卷 / 1-2期

关键词：

propyphenazone; spherical crystallization; compression behavior; brittle fracture;

D O I：

10.1016/S0378-5173(99)00455-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Spherical propyphenazone crystals were produced by an agglomeration technique using a three solvents system. After selecting the best propyphenazone solvent (ethyl alcohol), non-solvent (demineralized water) and bridging liquid (isopropyl acetate), several of their ratios were tested by a Sheffe ternary diagram. Micromeritic properties of agglomerates such as flowability, were improved and their compression behavior was investigated and compared to that of raw crystals. By compression and densification studies, along with tablet SEM analysis, we have been able to explain the compression mechanism of propyphenazone spherical crystals and have shown that their better tablet/ability can be due to the small size of individual particles in the agglomerates (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：95 / 106

页数：12

共 24 条

[11] Compression behavior of orthorhombic paracetamol [J].