Checkpoints and restriction points in bacteria and eukaryotic cells

被引:7
作者
Cooper, Stephen [1 ]
机构
[1] Univ Michigan, Sch Med, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA
关键词
D O I
10.1002/bies.20475
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Bacterial checkpoints, analogous to those proposed to exist in eukaryotic cells, offer insights into.the definition of a checkpoint. Examination of bacterial "checkpoint" or arrest phenomena illustrate problems with a too-casual application of the checkpoint idea to eukaryotic phenomena. The question raised here is whether there are cellular processes that "check" whether a cellular process is completed. It is possible that many eukaryotic "checkpoints" may not have "checking" functions. Some of the ubiquitous checkpoint phenomena widely described may be merely the result of the inherent incompleteness of earlier events preventing the initiation of subsequent events.
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页码:1035 / 1039
页数:5
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