PML nuclear bodies: from architecture to function

被引:168
|
作者
Lallemand-Breitenbach, Valerie [1 ,2 ,3 ]
de The, Hugues [1 ,2 ,3 ,4 ]
机构
[1] INSERM, U944, Equipe Labellise Ligue Natl Canc, CNRS,UMR 7212, Paris, France
[2] Univ Paris Diderot, Sorbonne Paris Cite, Hop St Louis, 1 Ave Claude Vellefaux, F-75475 Paris 10, France
[3] PSL Res Univ, Coll France, 11 Pl Marcelin Berthelot, F-75231 Paris 05, France
[4] Hop St Louis, AP HP, Serv Biochim, Paris, France
关键词
PROMYELOCYTIC LEUKEMIA PROTEIN; OXIDATIVE STRESS; UBIQUITIN LIGASE; RAR-ALPHA; PREMATURE SENESCENCE; CHROMATIN-STRUCTURE; MISFOLDED PROTEINS; ARSENIC TRIOXIDE; ONCOGENIC RAS; HUMAN-CELLS;
D O I
10.1016/j.ceb.2018.03.011
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
PML nuclear bodies are nucleated by the PML protein, which polymerizes into spherical shells where it concentrates many unrelated partner proteins. Emerging data has connected PML bodies to post-translational control, notably conjugation by SUMOs. High concentrations of SUMO-bound proteins were proposed to condense into liquid-like droplets and such phase transition may occur within NBs. Many stress pathways modulate NB formation and recent findings have directly implicated PML in oxidative stress response in vivo. PML may also undergo SUMO-dependent ubiquitination/degradation. We highlight recent advances linking PML to partner degradation and other adaptative post-translational modifications in the context of chromatin remodeling, telomere biology, senescence or viral infections.
引用
收藏
页码:154 / 161
页数:8
相关论文
共 50 条
  • [21] Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML
    Cao, TY
    Duprez, E
    Borden, KLB
    Freemont, PS
    Etkin, LD
    JOURNAL OF CELL SCIENCE, 1998, 111 : 1319 - 1329
  • [22] Nuclear organization of PML bodies in leukaemic and multiple myeloma cells
    Krejci, Jana
    Harnicarova, Andrea
    Kurova, Jana
    Uhlirova, Radka
    Kozubek, Stanislav
    Legartova, Sona
    Hajek, Roman
    Bartova, Eva
    LEUKEMIA RESEARCH, 2008, 32 (12) : 1866 - 1877
  • [23] PML-nuclear bodies are involved in cellular serum response
    Matsuzaki, K
    Minami, T
    Tojo, M
    Honda, Y
    Saitoh, N
    Nagahiro, S
    Saya, H
    Nakao, M
    GENES TO CELLS, 2003, 8 (03) : 275 - 286
  • [24] DNA viruses and viral proteins that interact with PML nuclear bodies
    Roger D Everett
    Oncogene, 2001, 20 : 7266 - 7273
  • [25] Patient mutations alter ATRX targeting to PML nuclear bodies
    Berube, Nathalie G.
    Healy, Jasmine
    Medina, Chantal F.
    Wu, Shaobo
    Hodgson, Todd
    Jagla, Magdalena
    Picketts, David J.
    EUROPEAN JOURNAL OF HUMAN GENETICS, 2008, 16 (02) : 192 - 201
  • [26] PML nuclear bodies and their spatial relationships in the mammalian cell nucleus
    Batty, Elizabeth
    Jensen, Kirsten
    Freemont, Paul
    FRONTIERS IN BIOSCIENCE-LANDMARK, 2009, 14 : 1182 - U7
  • [27] Emerging Role of PML Nuclear Bodies in Innate Immune Signaling
    Scherer, Myriam
    Stamminger, Thomas
    JOURNAL OF VIROLOGY, 2016, 90 (13) : 5850 - 5854
  • [28] Patient mutations alter ATRX targeting to PML nuclear bodies
    Nathalie G Bérubé
    Jasmine Healy
    Chantal F Medina
    Shaobo Wu
    Todd Hodgson
    Magdalena Jagla
    David J Picketts
    European Journal of Human Genetics, 2008, 16 : 192 - 201
  • [29] SCANning for PML nuclear bodies with Myeloid Zinc Finger 1
    Gallagher, Robert E.
    LEUKEMIA RESEARCH, 2008, 32 (11) : 1650 - 1652
  • [30] TTRAP is a novel PML nuclear bodies-associated protein
    Xu, Guan-lan
    Pan, Yu-kun
    Wang, Bing-yin
    Huang, Lu
    Tian, Ling
    Xue, Jing-lun
    Chen, Jin-zhong
    Jia, William
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 375 (03) : 395 - 398