Controllable Syntheses of Spiroindolenines and Benzazepinoindoles via Hexafluoroisopropanol-Mediated Redox-Neutral Cascade Process

被引：71

作者：

Bai, Guangxian ^{[1
]}

Dong, Fengying ^{[1
]}

Xu, Lubin ^{[1
]}

Liu, Yongjun ^{[2
]}

Wang, Liang ^{[1
]}

Li, Shuai-Shuai ^{[1
]}

机构：

[1] Qingdao Agr Univ, Coll Chem & Pharmaceut Sci, Qingdao 266109, Shandong, Peoples R China

[2] Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Zhengzhou Rd 53, Qingdao 266042, Shandong, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 16期

关键词：

C(SP(3))-H BOND FUNCTIONALIZATION; INTRAMOLECULAR HYDRIDE TRANSFER; C-H ACTIVATION; ENANTIOSELECTIVE SYNTHESIS; ALLYLIC DEAROMATIZATION; FLUORINATED ALCOHOLS; SPIROCYCLIC INDOLENINES; CYCLIC AMINALS; CONSTRUCTION; TRANSFER/CYCLIZATION;

D O I：

10.1021/acs.orglett.9b02051

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The pharmaceutically intriguing spiroindolenines incorporating tetrahydroquinoline were constructed via a hexafluoroisopropanol-promoted redox-neutral cascade cyclization from readily available starting materials. The benzazepinoindole skeletons could also be facilely accessed via one-pot sequential operation. Distinctive features of these transformations include their controllable access of the two privileged skeletons, high efficiency, simple operation, and mild reaction conditions.

引用

页码：6225 / 6230

页数：6

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