Synthesis and antiprotozoal activity of [1,3]oxazino[4,5,6-de]quinolines

被引：0
|
作者：
Meyer, T [1 ]
Geffken, D [1 ]
机构：
[1] Inst Pharm, Abt Pharmazeut Chem, D-20146 Hamburg, Germany
来源：
PHARMAZIE | 2004年 / 59卷 / 08期
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D O I：
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中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of 1,3-oxazino-anellated 4-amino-5-hydroxy-quinolines has been investigated. Cyclisation to 2,3-dihydro[1,3]oxazino[4,5,6-de]quinoline-2-ones/-2-thiones (2/3) was achieved by reaction with 1,1'-carbonyidiimidazole or 1,1'-thiocarbonyldiimidazole. Cyclocondensation with aldehydes yielded 2,3-dihydro[1,3]oxazino[4,5,6-de]quinoline-derivatives (5). All new tricyclic compounds exhibited weak antiprotozoal activity against Plasmodium falciparum.
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页码：593 / 596
页数：4
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