Synthesis and antiprotozoal activity of [1,3]oxazino[4,5,6-de]quinolines

被引：0

作者：

Meyer, T ^{[1
]}

Geffken, D ^{[1
]}

机构：

[1] Inst Pharm, Abt Pharmazeut Chem, D-20146 Hamburg, Germany

来源：

PHARMAZIE | 2004年 / 59卷 / 08期

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D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of 1,3-oxazino-anellated 4-amino-5-hydroxy-quinolines has been investigated. Cyclisation to 2,3-dihydro[1,3]oxazino[4,5,6-de]quinoline-2-ones/-2-thiones (2/3) was achieved by reaction with 1,1'-carbonyidiimidazole or 1,1'-thiocarbonyldiimidazole. Cyclocondensation with aldehydes yielded 2,3-dihydro[1,3]oxazino[4,5,6-de]quinoline-derivatives (5). All new tricyclic compounds exhibited weak antiprotozoal activity against Plasmodium falciparum.

引用

页码：593 / 596

页数：4

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