Copper-mediated pyrazole synthesis from 2,3-allenoates or 2-alkynoates, amines and nitriles

被引：51
作者：
Chen, Bo [1 ]
Zhu, Can [1 ]
Tang, Yang [1 ]
Ma, Shengming [1 ,2 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
[2] E China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Dept Chem, Shanghai 200062, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 57期
基金：
中国国家自然科学基金;
关键词：
STEREOSELECTIVE CONJUGATE ADDITION; BESTMANN-OHIRA REAGENT; ONE-POT SYNTHESIS; REGIOSELECTIVE SYNTHESIS; EFFICIENT SYNTHESIS; CATALYZED AMINATION; COMPLEXES; LIGANDS; ACCESS;
D O I：
10.1039/c4cc02856b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient copper-mediated three-component reaction of 2,3-allenoates or 2-alkynoates, amines, and nitriles affording fully substituted pyrazoles with a very nice diversity has been developed. A tandem conjugate addition, 1,2-addition, and N-N bond formation mechanism has been proposed for this diverse synthesis of pyrazoles based on mechanistic studies.
引用
收藏
页码：7677 / 7679
页数：3
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