Hepatoprotective coumarins and secoiridoids from Hydrangea paniculata

被引：28
作者：
Shi, Jing [1 ,2 ,3 ]
Li, Chuang-Jun [1 ,2 ]
Yang, Jing-Zhi [1 ,2 ]
Ma, Jie [1 ,2 ]
Wang, Chao [1 ,2 ]
Tang, Jia [1 ,2 ]
Li, Yan [1 ,2 ]
Chen, Hui [1 ,2 ]
Zhang, Dong-Ming [1 ,2 ]
机构：
[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
[2] Peking Union Med Coll, Beijing 100050, Peoples R China
[3] Shandong Acad Med Sci, Shandong Canc Hosp & Inst, Dept Pharmaceut, Jinan 250117, Peoples R China
来源：
FITOTERAPIA | 2014年 / 96卷
基金：
中国国家自然科学基金;
关键词：
Hydrangea paniculata; Coumarins; Secoiridoids; Hepatoprotective activity; GLUCOSIDES; LIGNANS; GLYCOSIDES; NEOLIGNANS; STEMS;
D O I：
10.1016/j.fitote.2014.04.015
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Three new coumarin glucosides (1, 3, 4), and a new secoiridoid glucoside (2), together with one known secoiridoid glucoside (5), were isolated from the stems of Hydrangea paniculata. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR, MS and CD spectra. At 10 mu M, compounds 1-5 showed hepatoprotective activities against DL-galactosamine-induced toxicity in HL-7702 cells. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：138 / 145
页数：8
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