Chiral separation of benzothiazole derivatives of amino acids using capillary zone electrophoresis

被引:14
|
作者
Novakova, Zuzana [1 ]
Pejchal, Vladimir [2 ]
Fischer, Jan [1 ]
Cesla, Petr [1 ]
机构
[1] Univ Pardubice, Fac Chem Technol, Dept Analyt Chem, Studentska 573, CZ-53210 Pardubice, Czech Republic
[2] Univ Pardubice, Fac Chem Technol, Inst Organ Chem & Technol, Pardubice, Czech Republic
关键词
amino acids; benzothiazole derivatives; capillary zone electrophoresis; dual cyclodextrin systems; polydimethylacrylamide-coated capillaries; STRUCTURAL-CHARACTERIZATION; BETA-CYCLODEXTRIN; ENANTIOSEPARATION; INHIBITORS; SELECTORS;
D O I
10.1002/jssc.201600689
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A method for the separation of enantiomers of leucine and phenylalanine benzothiazole derivatives as potential antimicrobial agents was developed using capillary zone electrophoresis with a dual cyclodextrin (CD) system. The best resolution of enantiomers was achieved in 100 mmol/L phosphate background electrolyte (pH 3.5) with the dual CD system consisting of 10 mmol/L of beta-CD with 10 mmol/L of 2-hydroxypropyl-beta-cyclodextrin for leucine derivative and 10 mmol/L of 2-hydroxypropyl-gamma-cyclodextrin for phenylalanine derivative, respectively. Under the optimal conditions, the highest enantioresolution of 1.25 was achieved in a noncoated-fused silica capillary at 17 degrees C and 24 kV applied voltage.
引用
收藏
页码:798 / 803
页数:6
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