The role of prostaglandins in the regulation of fish immunity

Prostaglandins (PGs) play a key role in the development of the immune response. These molecules are produced by a variety of cells including leukocytes, macrophages being the most important source of PGs for the innate immune system. PGs can elicit a variety of effects depending on the inflammatory milieu but also on the presence of specific PG receptors in many cell types. The biosynthetic pathways of prostaglandins, their production by cells of the immune system and their functions as immune modulators, have been poorly studied in fish. This review is based on the available published data and our own experience and highlights recent advances in our understanding of the role for PGs in the regulation of fish immunity. The evolutionary conservation of their functions in fish is proof of their importance as a regulator of the immune response. (C) 2015 Elsevier Ltd. All rights reserved.