Neutrophils in traumatic brain injury (TBI): friend or foe?

被引：107
|
作者：
Liu, Yang-Wuyue [1 ,2 ]
Li, Song [2 ]
Dai, Shuang-Shuang [1 ,3 ]
机构：
[1] Army Med Univ, Dept Biochem & Mol Biol, Chongqing 400038, Peoples R China
[2] Univ Pittsburgh, Sch Pharm, Ctr Pharmacogenet, Pittsburgh, PA 15261 USA
[3] Army Med Univ, Daping Hosp, State Key Lab Trauma Burn & Combined Injury, Mol Biol Ctr, Chongqing 400042, Peoples R China
来源：
JOURNAL OF NEUROINFLAMMATION | 2018年 / 15卷
基金：
中国国家自然科学基金;
关键词：
Neutrophils; Polymorphonuclear cell; Traumatic brain injury; Edema; Neuroinflammation; Blood-brain barrier; Neurodegeneration; Nerve recovery; CEREBRAL-ARTERY OCCLUSION; COLONY-STIMULATING FACTOR; ENDOTHELIAL GROWTH-FACTOR; ACTIVATED PROTEIN-KINASE; ISCHEMIC CELL-DAMAGE; SPINAL-CORD-INJURY; CEREBROSPINAL-FLUID; OXIDATIVE STRESS; IN-VITRO; BLOOD-FLOW;
D O I：
10.1186/s12974-018-1173-x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Our knowledge of the pathophysiology about traumatic brain injury (TBI) is still limited. Neutrophils, as the most abundant leukocytes in circulation and the first-line transmigrated immune cells at the sites of injury, are highly involved in the initiation, development, and recovery of TBI. Nonetheless, our understanding about neutrophils in TBI is obsolete, and mounting evidences from recent studies have challenged the conventional views. This review summarizes what is known about the relationships between neutrophils and pathophysiology of TBI. In addition, discussions are made on the complex roles as well as the controversial views of neutrophils in TBI.
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页数：18
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