Change in Long-Spacing Collagen in Descemet's Membrane of Diabetic Goto-Kakizaki Rats and Its Suppression by Antidiabetic Agents

被引：13

作者：

Akimoto, Yoshihiro ^{[1
]}

Sawada, Hajime ^{[2
]}

Ohara-Imaizumi, Mica ^{[3
]}

Nagamatsu, Shinya ^{[3
]}

Kawakami, Hayato ^{[1
]}

机构：

[1] Kyorin Univ, Sch Med, Dept Anat, Tokyo 1818611, Japan

[2] Yokohama City Univ, Sch Med, Dept Anat, Kanazawa Ku, Kanagawa 2360004, Japan

[3] Kyorin Univ, Sch Med, Dept Biochem, Tokyo 1818611, Japan

来源：

EXPERIMENTAL DIABETES RESEARCH | 2008年

关键词：

D O I：

10.1155/2008/818341

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We examined changes in the ultrastructure and localization of major extracellular matrix components, including 5 types of collagen (type I, III, IV, VI, and VIII), laminin, fibronectin, and heparan sulfate proteoglycan in Descemet's membrane of the cornea of diabetic GK rats. In the cornea of diabetic GK rats, more long-spacing collagen fibrils were observed in Descemet's membrane than in the membrane of the nondiabetic Wistar rats. Both GK and Wistar rats showed an age-dependent increase in the density of the long-spacing collagen. Immunoelectron microscopy showed that type VIII collagen was localized in the internodal region of the long-spacing collagen, which was not labelled by any of the other antibodies used. The antidiabetic agents nateglinide and glibenclamide significantly suppressed the formation of the long-spacing collagen in the diabetic rats. Long-spacing collagen would thus be a useful indicator for studying diabetic changes in the cornea and the effect of antidiabetic agents. Copyright (C) 2008 Yoshihiro Akimoto et al.

引用

页数：8

共 44 条

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