The albumin-bilirubin score as a predictor of outcomes in Japanese patients with PBC: an analysis using time-dependent ROC

被引：15

作者：

Ito, Takanori ^{[1
]}

Ishigami, Masatoshi ^{[1
]}

Morooka, Hikaru ^{[1
]}

Yamamoto, Kenta ^{[1
]}

Imai, Norihiro ^{[1
]}

Ishizu, Yoji ^{[1
]}

Honda, Takashi ^{[1
]}

Nishimura, Daisaku ^{[2
]}

Tada, Toshifumi ^{[3
]}

Yasuda, Satoshi ^{[4
]}

Toyoda, Hidenori ^{[4
]}

Kumada, Takashi ^{[5
]}

Fujishiro, Mitsuhiro ^{[1
]}

机构：

[1] Nagoya Univ, Dept Gastroenterol & Hepatol, Grad Sch Med, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan

[2] Toyota Kosei Hosp, Dept Gastroenterol, Toyota, Japan

[3] Himeji Red Cross Hosp, Dept Internal Med, Himeji, Hyogo, Japan

[4] Ogaki Municipal Hosp, Dept Gastroenterol & Hepatol, Gifu, Japan

[5] Gifu Kyoritsu Univ, Dept Nursing, Gifu, Japan

来源：

SCIENTIFIC REPORTS | 2020年 / 10卷 / 01期

关键词：

PRIMARY BILIARY-CIRRHOSIS; HEPATOCELLULAR-CARCINOMA; URSODEOXYCHOLIC ACID; BIOCHEMICAL RESPONSE; HEPATIC-FUNCTION; TERM SURVIVAL; MODEL; PROGNOSIS;

D O I：

10.1038/s41598-020-74732-3

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The albumin-bilirubin (ALBI) score is calculated using only serum albumin and bilirubin levels, and was developed as a simple method to assess hepatic function. In this study, a total of 409 patients with primary biliary cholangitis (PBC) were enrolled between March 1990 and October 2018. The predictive performances of the ALBI score and other well-established prognostic scores were compared using time-dependent receiver operating characteristic (ROC) analysis. During the follow-up period, 60 patients died, 45 due to liver-related diseases and 15 due to non-liver-related diseases, and 16 patients underwent liver transplantation. Time-dependent ROC analysis showed that the ALBI score has higher the areas under the ROC curves (AUROCs) than the Child-Pugh (C-P) score at each time point; AUROCs at 3, 5, and 10 years after the start of follow-up were 0.94, 0.91, and 0.90 for the ALBI score, and 0.89, 0.88, and 0.82 for the C-P score, respectively. The ALBI score showed the highest AUROCs within 2 years after the start of observation; beyond 2 years, however, the Mayo score had better prognostic ability for mortality and liver transplantation. The ALBI score/grade, derived from objective blood tests, and the Mayo score were superior prognostic tools in PBC patients.

引用

页数：9

共 31 条

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