Non-criteria Antiphospholipid Antibodies: a narrative review

被引:4
作者
Funke, Andreas [1 ]
Staub, Henrique Luiz [2 ]
Monticielo, Odirlei Andre [3 ]
Moreira Balbi, Gustavo Guimaraes [4 ]
Danowski, Adriana [5 ]
Santiago, Mittermayer Barreto [6 ,7 ]
Oliveira de Andrade, Danieli Castro [8 ]
Rego, Jozelia [9 ]
机构
[1] Univ Fed Parana UFPR, Hosp Clin, Serv Reumatol, Curitiba, PR, Brazil
[2] Pontificia Univ Catolica Rio Grande do Sul PUC RS, Serv Reumatol, Escola Med, Porto Alegre, RS, Brazil
[3] Univ Fed Rio Grande do Sul UFRGS, Hosp Clin Porto Alegre HCPA, Dept Med Interna, Serv Reumatol, Porto Alegre, RS, Brazil
[4] Univ Fed Juiz de Fora UFJF, Hosp Univ, Serv Reumatol, Juiz De Fora, MG, Brazil
[5] Hosp Fed Servidores Estado HFSE, Serv Reumatol, Rio De Janeiro, RJ, Brazil
[6] Univ Fed Bahia Hupes, Salvador, BA, Brazil
[7] Escola Baiana Med & Saude Publ, Salvador, BA, Brazil
[8] Univ Sao Paulo, Div Reumatol, Sao Paulo, SP, Brazil
[9] Univ Fed Goias UFG, Fac Med, Serv Reumatol, Goiania, Go, Brazil
来源
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA | 2020年 / 66卷 / 11期
关键词
Antiphospholipid syndrome; Antibodies; Antiphospholipid; Thrombosis/diagnosis; ANTI-ANNEXIN A5; IGA ANTICARDIOLIPIN; V ANTIBODIES; DOMAIN I; DIAGNOSIS; AUTOANTIBODIES; POSITIVITY; PHOSPHATIDYLETHANOLAMINE; MANIFESTATIONS; POLYMORPHISM;
D O I
10.1590/1806-9282.66.11.1595
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The 2006 Revised Sapporo Classification Criteria for Definite Antiphospholipid Syndrome included as laboratory criteria the tests for antiphospholipid antibodies whose accuracy was regarded as satisfactory according to the evidence available at that time. In practice, however, the sensitivity and specificity of these "criteria" of antiphospholipid antibodies are sometimes insufficient for identifying or ruling out antiphospholipid syndrome. It has been studied whether the accuracy of the laboratory diagnosis of the syndrome could be improved by testing for non-criteria antiphospholipid antibodies. In this work, we review evidence on the clinical associations and diagnostic value of the most commonly studied non-criteria antibodies, namely: antiphosphatidylethanolamine, anti-annexin A5, antiprothrombin, anti-phosphatidylserine/prothrombin complex, IgA anticardiolipin, and IgG anti-domain I of the beta 2 glycoprotein antibodies.
引用
收藏
页码:1595 / 1601
页数:7
相关论文
共 40 条
[1]   Anti-annexin A5 antibodies in women with spontaneous pregnancy loss [J].
Alijotas-Reig, Jaume ;
Ferrer-Oliveras, Raquel ;
Jose Rodrigo-Anoro, Maria ;
Farran-Codina, Inmaculada ;
Llurba-Olive, Elisa ;
Vilardell-Tarres, Miguel ;
Casellas-Caro, Manel .
MEDICINA CLINICA, 2010, 134 (10) :433-438
[2]   Evaluation of phosphatidylserine-dependent antiprothrombin antibody testing for the diagnosis of antiphospholipid syndrome: results of an international multicentre study [J].
Amengual, O. ;
Forastiero, R. ;
Sugiura-Ogasawara, M. ;
Otomo, K. ;
Oku, K. ;
Favas, C. ;
Alves, J. Delgado ;
Zigon, P. ;
Ambrozic, A. ;
Tomsic, M. ;
Ruiz-Arruza, I. ;
Ruiz-Irastorza, G. ;
Bertolaccini, M. L. ;
Norman, G. L. ;
Shums, Z. ;
Arai, J. ;
Murashima, A. ;
Tebo, A. E. ;
Gerosa, M. ;
Meroni, P. L. ;
Rodriguez-Pinto, I. ;
Cervera, R. ;
Swadzba, J. ;
Musial, J. ;
Atsumi, T. .
LUPUS, 2017, 26 (03) :266-276
[3]   Clinical Characterization of Antiphospholipid Syndrome by Detection of IgG Antibodies Against β2-Glycoprotein I Domain 1 and Domain 4/5: Ratio of Anti-Domain 1 to Anti-Domain 4/5 As a Useful New Biomarker for Antiphospholipid Syndrome [J].
Andreoli, Laura ;
Chighizola, Cecilia B. ;
Nalli, Cecilia ;
Gerosa, Maria ;
Borghi, M. Orietta ;
Pregnolato, Francesca ;
Grossi, Claudia ;
Zanola, Alessandra ;
Allegri, Flavio ;
Norman, Gary L. ;
Mahler, Michael ;
Meroni, Pier Luigi ;
Tincani, Angela .
ARTHRITIS & RHEUMATOLOGY, 2015, 67 (08) :2196-2204
[4]  
Atsumi T, 2000, ARTHRITIS RHEUM-US, V43, P1982, DOI 10.1002/1529-0131(200009)43:9<1982::AID-ANR9>3.0.CO
[5]  
2-2
[6]   The IgG and IgM isotypes of anti-annexin A5 antibodies: relevance for primary antiphospholipid syndrome [J].
Becarevic, Mirjana .
JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 2016, 42 (04) :552-557
[7]   The IgM isotype of anti-annexin A5 antibodies and multiple positivity of conventional antiphospholipid antibodies: increasing the number of clinical manifestations of primary antiphospholipid syndrome [J].
Becarevic, Mirjana ;
Stojanovic, Ljudmila ;
Ignjatovic, Svetlana ;
Dopsaj, Violeta .
CLINICAL RHEUMATOLOGY, 2016, 35 (05) :1361-1365
[8]   Deterioration of Thromboses in Primary Antiphospholipid Syndrome: TNF-alpha and Anti-Annexin A5 Antibodies [J].
Becarevic, Mirjana ;
Ignjatovic, Svetlana ;
Majkic-Singh, Nada .
CLINICAL LABORATORY, 2012, 58 (9-10) :1079-1084
[9]  
Bertolaccini ML, 1998, BRIT J RHEUMATOL, V37, P1229
[10]   Thin-layer chromatography immunostaining in detecting anti-phospholipid antibodies in seronegative anti-phospholipid syndrome [J].
Conti, F. ;
Alessandri, C. ;
Sorice, M. ;
Capozzi, A. ;
Longo, A. ;
Garofalo, T. ;
Misasi, R. ;
Bompane, D. ;
Hughes, G. R. V. ;
Khamashta, M. A. ;
Valesini, G. .
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2012, 167 (03) :429-437