Prognostic value of neutrophil-to-lymphocyte ratio in patients treated with concurrent chemoradiotherapy for locally advanced oesophageal cancer

被引:43
作者
Yoo, Eun Jin [1 ]
Park, Jun Chul [1 ,2 ]
Kim, Eun Hye [1 ,2 ]
Park, Chan Hyuk [1 ,2 ]
Shim, Choong Nam [1 ,2 ]
Lee, Hyun Jik [1 ,2 ]
Chung, Hyun Soo [1 ,2 ]
Lee, Hyuk [1 ,2 ]
Shin, Sung Kwan [1 ,2 ]
Lee, Sang Kil [1 ,2 ]
Lee, Chang Geol [3 ]
Lee, Yong Chan [1 ,2 ]
机构
[1] Yonsei Univ, Coll Med, Dept Internal Med, Seoul 120752, South Korea
[2] Yonsei Univ, Coll Med, Inst Gastroenterol, Seoul 120752, South Korea
[3] Yonsei Univ, Coll Med, Dept Radiol, Seoul 120752, South Korea
关键词
Concurrent chemoradiotherapy; Neutrophil-to-lymphocyte ratio; Oesophageal cancer; Prognosis; SYSTEMIC INFLAMMATORY RESPONSE; FOLLOW-UP; PHASE-II; SURVIVAL; CHEMOTHERAPY; RECURRENCE; CISPLATIN; SCORES;
D O I
10.1016/j.dld.2014.05.009
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: We performed a retrospective analysis of Asian patients with locally advanced oesophageal cancer to test the hypothesis that an elevated neutrophil-to-lymphocyte ratio is associated with a poor survival rate after definitive concurrent chemoradiotherapy. Methods: In total, 138 patients diagnosed with locally advanced oesophageal cancer (TNM classification of malignant tumours stage II or III) who were treated with definitive concurrent chemoradiotherapy between January 2005 and December 2010 were retrospectively analysed. Definitive concurrent chemoradiotherapy was performed using two different chemotherapy regimens. Results: The median follow-up duration was 39.5 months (range 1.1-93.4). The median progression-free survival was 14.0 months, and the median overall survival was 19.9 months. Compared with the low (<2.0) neutrophil-to-lymphocyte ratio group (n = 43, 31.2%), the high (>= 2.0) neutrophil-to-lymphocyte ratio group (n = 95, 68.8%) exhibited significant decreases in the durations of both progression-free survival and overall survival. Using multivariate analysis, an elevated neutrophil-to-lymphocyte ratio was also significantly associated with decreased progression-free survival (HR 1.799; 95% CI, 1.050-3.083; P = 0.032) and overall survival duration (HR 2.115; 95% CI, 1.193-3.749; P = 0.010). Conclusions: The pretreatment neutrophil-to-lymphocyte ratio is a useful prognostic marker in patients with locally advanced oesophageal cancer treated with definitive concurrent chemoradiotherapy. (C) 2014 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:846 / 853
页数:8
相关论文
共 34 条
[1]   Why do patients with weight loss have a worse outcome when undergoing chemotherapy for gastrointestinal malignancies? [J].
Andreyev, HJN ;
Norman, AR ;
Oates, J ;
Cunningham, D .
EUROPEAN JOURNAL OF CANCER, 1998, 34 (04) :503-509
[2]   Neutrophil to lymphocyte ratio may be predict of mortality in all conditions [J].
Balta, S. ;
Demirkol, S. ;
Unlu, M. ;
Arslan, Z. ;
Celik, T. .
BRITISH JOURNAL OF CANCER, 2013, 109 (12) :3125-3126
[3]   Neutrophil-Lymphocyte Ratio Predicts Medium-Term Survival Following Elective Major Vascular Surgery: A Cross-Sectional Study [J].
Bhutta, Hina ;
Agha, Riaz ;
Wong, Joy ;
Tang, Tjun Y. ;
Wilson, Yvonne G. ;
Walsh, Stewart R. .
VASCULAR AND ENDOVASCULAR SURGERY, 2011, 45 (03) :227-231
[4]   The systemic inflammatory response, performance status and survival in patients undergoing alpha-interferon treatment for advanced renal cancer [J].
Bromwich, E ;
McMillan, DC ;
Lamb, GWA ;
Vasey, PA ;
Aitchison, M .
BRITISH JOURNAL OF CANCER, 2004, 91 (07) :1236-1238
[5]   Chemoradiotherapy of locally advanced esophageal cancer - Long-term follow-up of a prospective randomized trial (RTOG 85-01) [J].
Cooper, JS ;
Guo, MD ;
Herskovic, A ;
Macdonald, JS ;
Martenson, JA ;
Al-Sarraf, M ;
Byhardt, R ;
Russell, AH ;
Beitler, JJ ;
Spencer, S ;
Asbell, SO ;
Graham, MV ;
Leichman, LL .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 281 (17) :1623-1627
[6]   Impact of nutritional parameter variations during definitive chemoradiotherapy in locally advanced oesophageal cancer [J].
Di Fiore, Aude ;
Lecleire, Stephane ;
Gangloff, Alice ;
Rigal, Olivier ;
Benyoucef, Ahmed ;
Blondin, Valerie ;
Sefrioui, David ;
Quiesse, Martine ;
Iwanicki-Caron, Isabelle ;
Michel, Pierre ;
Di Fiore, Frederic .
DIGESTIVE AND LIVER DISEASE, 2014, 46 (03) :270-275
[7]   Comparison of the Prognostic Value of Tumour- and Patient-Related Factors in Patients Undergoing Potentially Curative Resection of Oesophageal Cancer [J].
Dutta, Sumanta ;
Crumley, Andrew B. C. ;
Fullarton, Grant M. ;
Horgan, Paul G. ;
McMillan, Donald C. .
WORLD JOURNAL OF SURGERY, 2011, 35 (08) :1861-1866
[8]   Study of lymphocyte subpopulations in bone marrow in a model of protein-energy malnutrition [J].
Foci, Ricardo Ambrosio ;
Blatt, Solange Lucia ;
Beutler, Beatriz ;
Pereira, Juliana ;
Tsujita, Maristela ;
Vidal de Barros, Francisco Erivaldo ;
Borelli, Primavera .
NUTRITION, 2010, 26 (10) :1021-1028
[9]   Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: "N1" versus "N2" TAN [J].
Fridlender, Zvi G. ;
Sun, Jing ;
Kim, Samuel ;
Kapoor, Veena ;
Cheng, Guanjun ;
Ling, Leona ;
Worthen, G. Scott ;
Albelda, Steven M. .
CANCER CELL, 2009, 16 (03) :183-194
[10]  
Fujita Hiromasa, 2007, Nihon Geka Gakkai Zasshi, V108, P246