Analgesic Effect of Low Dose Nefopam Hydrochloride after Arthroscopic Rotator Cuff Repair: A Randomized Controlled Trial

被引:4
作者
Koh, Hyun Jung [1 ]
Joo, Jin [1 ]
Kim, Yang-Soo [2 ]
Lee, Yu Jung [1 ]
Yoo, Woojoo [1 ]
Lee, Min Soo [1 ]
Park, Hue Jung [1 ]
机构
[1] Catholic Univ Korea, Coll Med, Seoul St Marys Hosp, Dept Anesthesiol & Pain Med, Seoul 137701, South Korea
[2] Catholic Univ Korea, Coll Med, Seoul St Marys Hosp, Dept Orthoped, Seoul 137701, South Korea
关键词
rotator cuff; nefopam hydrochloride; interscalene block; postoperative pain; Visual Analog Scale (VAS); postoperative nausea and vomiting (PONV); PATIENT-CONTROLLED ANALGESIA; VISUAL ANALOG SCALE; DOUBLE-BLIND; POSTOPERATIVE NAUSEA; PAIN; SURGERY; HYPERALGESIA; PREVENTION; SAFETY;
D O I
10.3390/jcm8040553
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Arthroscopic rotator cuff repair causes acute postoperative hyperalgesia. Multimodal analgesia is preferable to opioid-based intravenous patient-controlled analgesia (IV-PCA) due to postoperative nausea and vomiting (PONV). We evaluated the effect of nefopam as a postoperative non-opioid analgesic after shoulder surgeries. A total of 180 adult patients were enrolled for arthroscopic rotator cuff repair. They were randomly assigned to nefopam (N) or control (C) groups and each group was reclassified according to the interscalene block (B) into NB, CB and NX, CX. Nefopam was applied at a constant dose intravenously during recovery. Pain scores were measured with a Visual Analogue Scale (VAS) before (T0), immediately after (T1), 30 min (T2) and 12 h (T3), 24 h (T4) and 48 h (T5) after surgery. There was no significant difference in demographic data. The overall VAS scores did not differ with regard to nefopam use, except for the NB group at T4 in intention to treat (ITT) analysis (p < 0.05). PONV occurred more frequently in the N group than in the C group (p < 0.05). Neither individual nor all risk factors were associated with PONV occurrence (p > 0.10). In conclusion, nefopam alone did not show a definite decrease in postoperative pain. It instead increased PONV regardless of risk factors.
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页数:13
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共 23 条
[11]   Interpretation of visual analog scale ratings and change scores: A reanalysis of two clinical trials of postoperative pain [J].
Jensen, MP ;
Chen, C ;
Brugger, AM .
JOURNAL OF PAIN, 2003, 4 (07) :407-414
[12]   Opioid sparing effect and safety of nefopam in patient controlled analgesia after laparotomy: A randomized, double blind study [J].
Jin, Hyun Seung ;
Kim, Yong Chul ;
Yoo, Yongjae ;
Lee, Changsoon ;
Cho, Chan Woo ;
Kim, Won-joong .
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2016, 44 (04) :844-854
[13]   Rediscovery of Nefopam for the Treatment of Neuropathic Pain [J].
Kim, Kyung Hoon ;
Abdi, Salahadin .
KOREAN JOURNAL OF PAIN, 2014, 27 (02) :103-111
[14]   The analgesic efficacy and safety of nefopam in patient-controlled analgesia after cardiac surgery: A randomized, double-blind, prospective study [J].
Kim, Kyungmi ;
Kim, Wook-Jong ;
Choi, Dae-Kee ;
Lee, Yoon Kyung ;
Choi, In-Cheol ;
Sim, Ji-Yeon .
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2014, 42 (03) :684-692
[15]   Long-Term Pain Vulnerability After Surgery in Rats: Prevention by Nefopam, an Analgesic with Antihyperalgesic Properties [J].
Laboureyras, Emilie ;
Chateauraynaud, Jeremy ;
Richebe, Philippe ;
Simonnet, Guy .
ANESTHESIA AND ANALGESIA, 2009, 109 (02) :623-631
[16]   Ondansetron Does Not Attenuate the Analgesic Efficacy of Nefopam [J].
Lu, Kai-Zhi ;
Shen, Hong ;
Chen, Yan ;
Li, Min-Guang ;
Tian, Guo-Pin ;
Chen, Jie .
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 2013, 10 (12) :1790-1794
[17]   Preventive Analgesic Efficacy of Nefopam in Acute and Chronic Pain After Breast Cancer Surgery A Prospective, Double-Blind, and Randomized Trial [J].
Na, Hyo-Seok ;
Oh, Ah-Young ;
Koo, Bon-Wook ;
Lim, Dae-Jin ;
Ryu, Jung-Hee ;
Han, Ji-Won .
MEDICINE, 2016, 95 (20)
[18]   Effects of Nefopam on Early Postoperative Hyperalgesia After Cardiac Surgery [J].
Richebe, Philippe ;
Picard, Walter ;
Rivat, Cyril ;
Jelacic, Srdjan ;
Branchard, Olivier ;
Leproust, Sandy ;
Cahana, Alex ;
Janvier, Gerard .
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 2013, 27 (03) :427-435
[19]   Can postoperative nausea and vomiting be predicted? [J].
Sinclair, DR ;
Chung, F ;
Mezei, G .
ANESTHESIOLOGY, 1999, 91 (01) :109-118
[20]   Pain after shoulder arthroscopy: A prospective study on 231 cases [J].
Stiglitz, Y. ;
Gosselin, O. ;
Sedaghatian, J. ;
Sirveaux, F. ;
Mole, D. .
ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH, 2011, 97 (03) :260-266