Analgesic Effect of Low Dose Nefopam Hydrochloride after Arthroscopic Rotator Cuff Repair: A Randomized Controlled Trial

被引:4
|
作者
Koh, Hyun Jung [1 ]
Joo, Jin [1 ]
Kim, Yang-Soo [2 ]
Lee, Yu Jung [1 ]
Yoo, Woojoo [1 ]
Lee, Min Soo [1 ]
Park, Hue Jung [1 ]
机构
[1] Catholic Univ Korea, Coll Med, Seoul St Marys Hosp, Dept Anesthesiol & Pain Med, Seoul 137701, South Korea
[2] Catholic Univ Korea, Coll Med, Seoul St Marys Hosp, Dept Orthoped, Seoul 137701, South Korea
来源
JOURNAL OF CLINICAL MEDICINE | 2019年 / 8卷 / 04期
关键词
rotator cuff; nefopam hydrochloride; interscalene block; postoperative pain; Visual Analog Scale (VAS); postoperative nausea and vomiting (PONV); PATIENT-CONTROLLED ANALGESIA; VISUAL ANALOG SCALE; DOUBLE-BLIND; POSTOPERATIVE NAUSEA; PAIN; SURGERY; HYPERALGESIA; PREVENTION; SAFETY;
D O I
10.3390/jcm8040553
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Arthroscopic rotator cuff repair causes acute postoperative hyperalgesia. Multimodal analgesia is preferable to opioid-based intravenous patient-controlled analgesia (IV-PCA) due to postoperative nausea and vomiting (PONV). We evaluated the effect of nefopam as a postoperative non-opioid analgesic after shoulder surgeries. A total of 180 adult patients were enrolled for arthroscopic rotator cuff repair. They were randomly assigned to nefopam (N) or control (C) groups and each group was reclassified according to the interscalene block (B) into NB, CB and NX, CX. Nefopam was applied at a constant dose intravenously during recovery. Pain scores were measured with a Visual Analogue Scale (VAS) before (T0), immediately after (T1), 30 min (T2) and 12 h (T3), 24 h (T4) and 48 h (T5) after surgery. There was no significant difference in demographic data. The overall VAS scores did not differ with regard to nefopam use, except for the NB group at T4 in intention to treat (ITT) analysis (p < 0.05). PONV occurred more frequently in the N group than in the C group (p < 0.05). Neither individual nor all risk factors were associated with PONV occurrence (p > 0.10). In conclusion, nefopam alone did not show a definite decrease in postoperative pain. It instead increased PONV regardless of risk factors.
引用
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页数:13
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