2-Alkyl/aryl/heteroarylbenzothiazole ring systems from o-aminothiophenol and its derivatives as versatile synthons

被引：4

作者：

Chandrasekhar, Batchu ^{[1
]}

机构：

[1] Vindhya Pharma I Pvt Ltd, IDA, Proc Res & Dev, Hyderabad 502325, Andhra Pradesh, India

来源：

JOURNAL OF SULFUR CHEMISTRY | 2014年 / 35卷 / 05期

关键词：

o-aminothiophenol and its derivatives; Schiff bases; oxidative cyclization; green synthesis; tandem reaction; ONE-POT SYNTHESIS; HIGHLY EFFICIENT CATALYST; SOLID-PHASE SYNTHESIS; SILICA SULFURIC-ACID; 2-SUBSTITUTED BENZOXAZOLES; MICHAEL ADDITION; IONIC LIQUID; HOMOGENEOUS CATALYST; MEDIATED SYNTHESIS; OPTICAL-PROPERTIES;

D O I：

10.1080/17415993.2014.934245

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This review describes the reactions of o-aminothiophenol and its derivatives as building blocks for the synthesis of polyfunctionalized benzothiazoles with pharmacological interest. Annelated benzothiazoles were prepared by a cyclocondensation reaction of o-aminothiophenol and its derivatives with carbonyl and other functionalities. In the case of carbonyl functions, this reaction takes place by a nucleophilic addition, followed by cyclization concomitant with the elimination of water. The objective of this survey is to provide a comprehensive account of the synthesis of various benzothiazole systems and their potential to develop better chemotherapeutic agents. [GRAPHICS] .

引用

页码：538 / 586

页数：49

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