Current Panorama and Challenges for Neoadjuvant Cancer Immunotherapy

被引：41

作者：

Benitez, Jose Carlos ^{[1
]}

Remon, Jordi ^{[2
]}

Besse, Benjamin ^{[1
,3
]}

机构：

[1] Gustave Roussy, Dept Canc Med, Villejuif, France

[2] HM Hosp, Hosp HM Delfos, Ctr Integral Oncol Clara Campal HM CIOCC, Dept Med Oncol, Barcelona, Spain

[3] Univ Paris Saclay, Orsay, France

来源：

CLINICAL CANCER RESEARCH | 2020年 / 26卷 / 19期

关键词：

CELL LUNG-CANCER; MAJOR PATHOLOGICAL RESPONSE; STAGE-III MELANOMA; BLADDER-CANCER; OPEN-LABEL; HIGH-RISK; CHEMOTHERAPY; THERAPY; SURVIVAL; OUTCOMES;

D O I：

10.1158/1078-0432.CCR-19-3255

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immune checkpoint inhibitors (ICI) may overcome cancer cells' ability to evade the immune system and proliferate. The long-term benefit of ICI in the metastatic setting led to evaluate neoadjuvant ICI approaches in several tumor types such as melanoma, non-small cell lung cancer, and breast and bladder cancer. We summarize the current evidence for the efficacy of neoadjuvant ICI in cancer and discuss several unresolved challenges, including the role of adjuvant treatment after neoadjuvant ICI, the efficacy in oncogenic addicted tumors, and standardizing pathologic assessment.

引用

页码：5068 / 5077

页数：10

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