Helicobacter pylori Outer Membrane Protein-Related Pathogenesis

被引：70

作者：

Matsuo, Yuichi ^{[1
]}

Kido, Yasutoshi ^{[1
]}

Yamaoka, Yoshio ^{[1
,2
,3
]}

机构：

[1] Oita Univ, Fac Med, Dept Environm & Prevent Med, 1-1 Idaigaoka,Hasama Machi, Yufu City, Oita 8795593, Japan

[2] Michael E DeBakey VA Med Ctr, Dept Med Gastroenterol, Houston, TX 77030 USA

[3] Baylor Coll Med, Houston, TX 77030 USA

来源：

TOXINS | 2017年 / 9卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Helicobacter pylori; outer membrane protein; pathogenesis; Type IV secretion system; CARBOXY-TERMINAL PHENYLALANINE; COMPLETE GENOME SEQUENCE; GASTRIC INFLAMMATION; ADHESIN SABA; HOPQ ALLELES; BINDING; OIPA; IV; CAGA; EXPRESSION;

D O I：

10.3390/toxins9030101

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Helicobacter pylori colonizes the human stomach and induces inflammation, and in some cases persistent infection can result in gastric cancer. Attachment to the gastric mucosa is the first step in establishing bacterial colonization, and outer membrane proteins (OMPs) play a pivotal role in binding to human cells. Some OMP interaction molecules are known in H. pylori, and their associated host cell responses have been gradually clarified. Many studies have demonstrated that OMPs are essential to CagA translocation into gastric cells via the Type IV secretion system of H. pylori. This review summarizes the mechanisms through which H. pylori utilizes OMPs to colonize the human stomach and how OMPs cooperate with the Type IV secretion system.

引用

页数：9

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