Collagen Cross-Linking in the Management of Microbial Keratitis

被引：10

作者：

Bonzano, Chiara ^{[1
,2
]}

Di Zazzo, Antonio ^{[3
]}

Barabino, Stefano ^{[1
,2
]}

Coco, Giulia ^{[4
]}

Traverso, Carlo Enrico ^{[1
,2
]}

机构：

[1] Univ Genoa, Di NOGMI, Clin Oculist, Viale Benedetto XV 5, I-16132 Genoa, Italy

[2] Osped Policlin San Martino, Viale Benedetto XV 5, I-16132 Genoa, Italy

[3] GB Bietti Fdn, IRCCS, Dept Ophthalmol, Rome, Italy

[4] Univ Roma Tor Vergata, Dept Ophthalmol, Rome, Italy

来源：

OCULAR IMMUNOLOGY AND INFLAMMATION | 2019年 / 27卷 / 03期

关键词：

Corneal cross-linking; microbial keratitis; PACK-CXL; riboflavin; ultraviolet light A; ULTRAVIOLET-A LIGHT; IN-VITRO EFFICACY; CORNEAL COLLAGEN; INFECTIOUS KERATITIS; ACANTHAMOEBA-KERATITIS; BACTERIAL KERATITIS; RISK-FACTORS; PROGRESSIVE KERATOCONUS; FORTIFIED ANTIBIOTICS; PREDISPOSING FACTORS;

D O I：

10.1080/09273948.2017.1414856

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Increasing resistance to antimicrobial agents has contributed to an elevated risk of complications of infectious keratitis. Corneal collagen cross-linking (CXL) has been widely adopted for the management of keratoconus and post-refractive surgery corneal ectasia. It has recently been introduced as an option for treating keratitis due to multidrug resistant organisms. The purpose of this review is to discuss the rationale, safety, and evidence for CXL in infectious keratitis and its possible effect on ocular surface inflammation. Published data show that CXL is effective and safe as an adjunct to antibiotic treatment in selected cases of bacterial keratitis. The benefit of CXL probably varies according to the etiology of the infection.

引用

页码：507 / 512

页数：6

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