TAFRO syndrome successfully treated with tocilizumab: A case report and systematic review

被引：19

作者：

Sakai, Kazuya ^{[1
]}

Maeda, Takeshi ^{[1
]}

Kuriyama, Akira ^{[2
]}

Shimada, Noriaki ^{[3
]}

Notohara, Kenji ^{[4
]}

Ueda, Yasunori ^{[1
]}

机构：

[1] Kurashiki Cent Hosp, Dept Haematol Oncol, 1-1-1 Miwa, Kurashiki, Okayama 7108602, Japan

[2] Kurashiki Cent Hosp, Dept Gen Med, Kurashiki, Okayama, Japan

[3] Kurashiki Cent Hosp, Dept Nephrol, Kurashiki, Okayama, Japan

[4] Kurashiki Cent Hosp, Dept Anat Pathol, Kurashiki, Okayama, Japan

来源：

MODERN RHEUMATOLOGY | 2018年 / 28卷 / 03期

关键词：

Castleman's disease; Liver injury; Systematic review; Thrombocytopenia; anasarca; fever; reticulin fibrosis; and organomegaly syndrome; Tocilizumab; MULTICENTRIC CASTLEMANS-DISEASE; IDIOPATHIC PLASMACYTIC LYMPHADENOPATHY; ANTI-INTERLEUKIN-6 RECEPTOR ANTIBODY; CYCLOSPORINE-A; THROMBOCYTOPENIA; ANASARCA; MYELOFIBROSIS; ASCITES; FEVER; CONSTELLATION;

D O I：

10.3109/14397595.2015.1120389

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO) syndrome is considered as a unique clinicopathologic variant of multicentric Castleman's disease and is recently reported in Japan. This entity represents a severe inflammatory state leading to organ failures such as severe liver dysfunction seen in our case, and can be treated by immunosuppressive agents, steroids, and cyclosporine shown in several case reports. A systematic review and our case suggest the potential utility of tocilizumab as a treatment for TAFRO syndrome.

引用

页码：564 / 569

页数：6

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